Mouhayar Youssef, Sharara Fady I
Department of OB/GYN, University of Miami/Jackson Memorial Hospital, Miami, FL, USA.
Virginia Center for Reproductive Medicine, 11150 Sunset Hills Rd, Suite, Reston, VA, 100, USA.
J Assist Reprod Genet. 2017 Jul;34(7):831-837. doi: 10.1007/s10815-017-0922-6. Epub 2017 Apr 12.
The study aims to describe two promising therapeutic options for resistant "thin" endometrium in fertility treatment: granulocyte colony-stimulating factor (G-CSF) and stem cell therapy.
A review of the scientific literature related to patients with thin endometrium undergoing fertility treatment.
Sufficient endometrial growth is fundamental for embryo implantation. Whether idiopathic or resulting from an underlying pathology, a thin endometrium of <7 mm is associated with lower probability of pregnancy; however, no specific thickness excludes the occurrence of pregnancy. We specifically reviewed two relatively new treatment options for resistant thin lining: intrauterine G-CSF and stem cell therapy. The majority of the reviewed trials showed a significant benefit for intrauterine G-CSF infusion in improving endometrial thickness and pregnancy rates. Early results of stem cell therapy trials seem promising.
EMT <7 mm is linked to lower probability of pregnancy in assisted reproductive technology. Intrauterine G-CSF infusion appears to be a potentially successful treatment option for resistant cases, while stem cell therapy seems to be a promising new treatment modality in severely refractory cases.
本研究旨在描述生育治疗中针对抵抗性“薄型”子宫内膜的两种有前景的治疗选择：粒细胞集落刺激因子（G-CSF）和干细胞疗法。
对接受生育治疗的薄型子宫内膜患者的相关科学文献进行综述。
足够的子宫内膜生长是胚胎着床的基础。无论是特发性的还是由潜在病理导致的，厚度<7mm的薄型子宫内膜与较低的妊娠概率相关；然而，没有特定的厚度能排除妊娠的发生。我们特别综述了针对抵抗性薄内膜的两种相对较新的治疗选择：宫腔内注射G-CSF和干细胞疗法。大多数综述试验表明，宫腔内注射G-CSF在改善子宫内膜厚度和妊娠率方面有显著益处。干细胞疗法试验的早期结果似乎很有前景。
在辅助生殖技术中，子宫内膜厚度<7mm与较低的妊娠概率相关。宫腔内注射G-CSF似乎是抵抗性病例的一种潜在成功治疗选择，而干细胞疗法似乎是严重难治性病例中一种有前景的新治疗方式。
