Demoré Béatrice, Mangin Lucie, Tebano Gianpiero, Pulcini Céline, Thilly Nathalie
CHRU Nancy, Pharmacie Brabois Adultes, Nancy, 54000, France.
Université de Lorraine, UMR 7565 (SRSMC) CNRS, Nancy, 54000, France.
Infection. 2017 Aug;45(4):513-520. doi: 10.1007/s15010-017-1015-2. Epub 2017 Apr 12.
To evaluate knowledge and behaviours concerning antibiotics and bacterial resistance in the French population, and to identify the socio-demographic factors associated with a high level of such knowledge and appropriate behaviours.
A survey of the general population was conducted in 2015 in northeast France. The 44-item standardized questionnaire used comprised three parts, focusing on the assessment of knowledge, behaviours, and the collection of main socio-demographic characteristics of respondents (gender, age, having children, education level, and profession). The association of these characteristics with the level of knowledge about antibiotics, and with related behaviours, as well as the association between knowledge and behaviours was identified in a bivariate analysis (Chi-2 tests) and a multivariate analysis when necessary (logistic regression).
The 200 respondents had quite a good level of knowledge about antibiotics for several points: the lack of effectiveness of antibiotics for colds (75.5%), the risk of inefficacy of antibiotics when misused (93%), and the effects of overconsumption on bacterial resistance (92%). Conversely, the effects of different doses and treatment durations on resistance were less well known. Inappropriate behaviours were frequent, especially non-adherence to dosing schedules and to treatment duration (35.5%), and self-medication practices (18%). Female gender, older age, and having children were independently associated with a good level of knowledge. A low level of education and older age were associated with appropriate behaviours.
No association was found between knowledge and behaviours, highlighting the relevance of national public information campaigns to limit the misuse of antibiotics.
评估法国人群中有关抗生素及细菌耐药性的知识和行为，并确定与高水平此类知识及恰当行为相关的社会人口学因素。
2015年在法国东北部对普通人群进行了一项调查。所使用的包含44个条目的标准化问卷由三部分组成，重点在于知识评估、行为评估以及收集受访者的主要社会人口学特征（性别、年龄、有无子女、教育水平和职业）。在双变量分析（卡方检验）以及必要时的多变量分析（逻辑回归）中，确定了这些特征与抗生素知识水平、相关行为之间的关联，以及知识与行为之间的关联。
200名受访者在几个方面对抗生素有相当不错的了解程度：抗生素对感冒无效（75.5%）、滥用抗生素时无效的风险（93%）以及过度使用对抗菌耐药性的影响（92%）。相反，不同剂量和疗程对抗菌耐药性的影响则了解较少。不恰当行为很常见，尤其是不遵守给药时间表和疗程（35.5%）以及自我用药行为（18%）。女性、年龄较大以及有子女与良好的知识水平独立相关。低教育水平和年龄较大与恰当行为相关。
未发现知识与行为之间存在关联，这凸显了全国性公共宣传活动对于限制抗生素滥用的重要性。
