Department of Chemistry, ‡Department of Polymer Science and Engineering, §The Center for Bioactive Delivery, Institute for Applied Life Sciences, and ∥Molecular and Cellular Biology Program, University of Massachusetts , Amherst, Massachusetts 01003-9336, United States.
J Am Chem Soc. 2017 Apr 26;139(16):5676-5679. doi: 10.1021/jacs.7b01214. Epub 2017 Apr 13.
Trafficking proteins inside cells is an emerging field with potential utility in basic cell biology and biological therapeutics. A robust and sustainable delivery strategy demands not only good protection of the cargo but also reversibility in conjugation and activity. We report a protein-templated polymer self-assembly strategy for forming a sheath around the proteins and then tracelessly releasing them in the cytosol. The versatility of the approach, demonstrated here, suggests that the strategy is compatible with a wide array of biologics.
细胞内蛋白质运输是一个新兴领域，在基础细胞生物学和生物治疗中有潜在的应用价值。一个稳健且可持续的递药策略不仅需要对货物有良好的保护，还需要在连接和活性上具有可逆性。我们报告了一种蛋白质模板聚合物自组装策略，用于在蛋白质周围形成鞘，然后在细胞质中无痕迹地释放它们。这里展示的方法的多功能性表明，该策略与广泛的生物制剂兼容。
