Lo C H, Kritchevsky D
J Med. 1978;9(4):313-36.
The activity of N-acetyl hexosaminidase (beta-2-acetamido-2-deoxy-D-glucoside:N-acetamido-deoxyglucohydrolase, E.C. 3.2.1.30) was significantly greater in sera of patients with solid malignant tumors than in sera of healthy volunteers or of patients with nonmalignant ailments. The increased activity was found in the two major isozymes, hexosaminidase A and hexosaminidase B, but the increase in the latter isozyme was more prominent than in the former. Measurement of the levels of the hexosaminidase isozymes may provide an ancillary diagnostic test for malignancy.
实体恶性肿瘤患者血清中N - 乙酰己糖胺酶（β - 2 - 乙酰氨基 - 2 - 脱氧 - D - 葡萄糖苷：N - 乙酰氨基脱氧葡萄糖水解酶，E.C. 3.2.1.30）的活性显著高于健康志愿者或非恶性疾病患者的血清。在两种主要同工酶，即己糖胺酶A和己糖胺酶B中均发现活性增加，但后一种同工酶的增加比前一种更为显著。检测己糖胺酶同工酶水平可能为恶性肿瘤提供辅助诊断测试。
