Ai Er Ken Ai Bi Bai, Ma Zhi-Hua, Xiong Dai-Qin, Xu Pei-Ru
Department of Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2017 Apr;19(4):414-418. doi: 10.7499/j.issn.1008-8830.2017.04.011.
To investigate the clinical features of invasive candidiasis in children and the risk factors for Candida bloodstream infection.
A retrospective study was performed on 134 children with invasive candidiasis and hospitalized in 5 tertiary hospitals in Urumqi, China, between January 2010 and December 2015. The Candida species distribution was investigated. The clinical data were compared between the patients with and without Candida bloodstream infection. The risk factors for Candida bloodstream infection were investigated using multivariate logistic regression analysis.
A total of 134 Candida strains were isolated from 134 children with invasive candidiasis, and non-albicans Candida (NAC) accounted for 53.0%. The incidence of invasive candidiasis in the PICU and other pediatric wards were 41.8% and 48.5% respectively. Sixty-eight patients (50.7%) had Candida bloodstream infection, and 45 patients (33.6%) had Candida urinary tract infection. There were significant differences in age, rate of use of broad-spectrum antibiotics, and incidence rates of chronic renal insufficiency, heart failure, urinary catheterization, and NAC infection between the patients with and without Candida bloodstream infection (P<0.05). The multivariate logistic regression analysis showed that younger age (1-24 months) (OR=6.027) and NAC infection (OR=1.020) were the independent risk factors for Candida bloodstream infection.
The incidence of invasive candidiasis is similar between the PICU and other pediatric wards. NAC is the most common species of invasive candidiasis. Candida bloodstream infection is the most common invasive infection. Younger age (1-24 months) and NAC infection are the risk factors for Candida bloodstream infection.
探讨儿童侵袭性念珠菌病的临床特征及念珠菌血流感染的危险因素。
对2010年1月至2015年12月在中国乌鲁木齐5家三级医院住院的134例侵袭性念珠菌病患儿进行回顾性研究。调查念珠菌菌种分布情况。比较有和没有念珠菌血流感染的患者的临床资料。采用多因素logistic回归分析探讨念珠菌血流感染的危险因素。
从134例侵袭性念珠菌病患儿中共分离出134株念珠菌，非白色念珠菌（NAC）占53.0%。儿科重症监护病房（PICU）和其他儿科病房侵袭性念珠菌病的发病率分别为41.8%和48.5%。68例（50.7%）患者发生念珠菌血流感染，45例（33.6%）患者发生念珠菌尿路感染。有和没有念珠菌血流感染的患者在年龄、广谱抗生素使用率、慢性肾功能不全、心力衰竭、导尿和NAC感染发生率方面存在显著差异（P<0.05）。多因素logistic回归分析显示，年龄较小（1 - 24个月）（OR = 6.027）和NAC感染（OR = 1.020）是念珠菌血流感染的独立危险因素。
PICU和其他儿科病房侵袭性念珠菌病的发病率相似。NAC是侵袭性念珠菌病最常见的菌种。念珠菌血流感染是最常见的侵袭性感染。年龄较小（1 - 24个月）和NAC感染是念珠菌血流感染的危险因素。
