Yao Dongting, Chen Jia, Zhang Guanyi
Department of Laboratory Medicine, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People's Republic of China.
Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, 200030, People's Republic of China.
Infect Drug Resist. 2025 May 5;18:2271-2282. doi: 10.2147/IDR.S510389. eCollection 2025.
Given the increasing incidence of invasive infection worldwide, particularly among immunocompromised and critically ill patients, we aimed to assess the distribution of species as well as their clinical features and responses to common antifungal agents through a retrospective analysis of patient data in a Chinese traditional medicine hospital.
In this retrospective single-center study, we analyzed data from 301 patients with invasive infection at our hospital between 2020 and 2022, We report the clinical characteristics, species distribution, and in-vitro susceptibility profiles of isolates to eight antifungal agents. Logistic regression analysis was employed for multivariate assessments to analysis the correlation between clinical symptoms and prognosis. Kaplan-Meier survival analysis was used for survival analysis.
was the most prevalent species (38.9%, 117/301), followed by (28.2%, 85/301) and (22.9%, 69/301). Age, department of admission, underlying disease, and presence of risk factors differed significantly among patients with different infections. Kaplan-Meier survival analysis showed that infection was associated with a higher seven-day mortality than other spp. infections. Multivariate logistic regression analyses showed that age, presence of sepsis, insertion of the central venous catheter, and administration of total parenteral nutrition were independent predictors of mortality. was most resistant to azoles, with 36.26% of the strains being fluconazole-resistant, 35.16% being non-wild type to itraconazole, and 34.52% being non-wild type to voriconazole. Non-susceptibility to echinocandins was found in 11 strains (10.39%, 3.90%, and 1.30% of isolates for caspofungin, micafungin, and anidulafungin, respectively).
Our findings underscore the need for close monitoring of azole resistance in and echinocandin resistance in , and highlight age, sepsis, CVC insertion, and parenteral nutrition as key predictors of mortality in invasive infections.
鉴于全球侵袭性感染的发病率不断上升，尤其是在免疫功能低下和危重症患者中，我们旨在通过对一家中医医院患者数据的回顾性分析，评估菌种分布及其临床特征以及对常用抗真菌药物的反应。
在这项回顾性单中心研究中，我们分析了2020年至2022年间我院301例侵袭性感染患者的数据。我们报告了分离株的临床特征、菌种分布以及对八种抗真菌药物的体外药敏谱。采用逻辑回归分析进行多变量评估，以分析临床症状与预后之间的相关性。采用Kaplan-Meier生存分析进行生存分析。
[具体菌种名称1]是最常见的菌种（38.9%，117/301），其次是[具体菌种名称2]（28.2%，85/301）和[具体菌种名称3]（22.9%，69/301）。不同[具体菌种名称]感染患者的年龄、入院科室、基础疾病和危险因素存在显著差异。Kaplan-Meier生存分析表明，[具体菌种名称1]感染患者的7天死亡率高于其他[具体菌种名称]感染患者。多变量逻辑回归分析表明，年龄、脓毒症的存在、中心静脉导管的插入以及全胃肠外营养的使用是死亡率的独立预测因素。[具体菌种名称1]对唑类药物耐药性最强，36.26%的菌株对氟康唑耐药，35.16%的菌株对伊曲康唑非野生型，34.52%的菌株对伏立康唑非野生型。11株菌株对棘白菌素不敏感（分别占卡泊芬净、米卡芬净和阿尼芬净分离株的10.39%、3.90%和1.30%）。
我们的研究结果强调了密切监测[具体菌种名称1]对唑类药物的耐药性以及[具体菌种名称2]对棘白菌素的耐药性的必要性，并突出了年龄、脓毒症、中心静脉导管插入和胃肠外营养是侵袭性[具体菌种名称]感染死亡率的关键预测因素。
