Clinical Features, Outcomes, and Antifungal Susceptibility Profiles of Invasive Infections in a Tertiary Care Hospital in China.

PURPOSE

Given the increasing incidence of invasive infection worldwide, particularly among immunocompromised and critically ill patients, we aimed to assess the distribution of species as well as their clinical features and responses to common antifungal agents through a retrospective analysis of patient data in a Chinese traditional medicine hospital.

PATIENTS AND METHODS

In this retrospective single-center study, we analyzed data from 301 patients with invasive infection at our hospital between 2020 and 2022, We report the clinical characteristics, species distribution, and in-vitro susceptibility profiles of isolates to eight antifungal agents. Logistic regression analysis was employed for multivariate assessments to analysis the correlation between clinical symptoms and prognosis. Kaplan-Meier survival analysis was used for survival analysis.

RESULTS

was the most prevalent species (38.9%, 117/301), followed by (28.2%, 85/301) and (22.9%, 69/301). Age, department of admission, underlying disease, and presence of risk factors differed significantly among patients with different infections. Kaplan-Meier survival analysis showed that infection was associated with a higher seven-day mortality than other spp. infections. Multivariate logistic regression analyses showed that age, presence of sepsis, insertion of the central venous catheter, and administration of total parenteral nutrition were independent predictors of mortality. was most resistant to azoles, with 36.26% of the strains being fluconazole-resistant, 35.16% being non-wild type to itraconazole, and 34.52% being non-wild type to voriconazole. Non-susceptibility to echinocandins was found in 11 strains (10.39%, 3.90%, and 1.30% of isolates for caspofungin, micafungin, and anidulafungin, respectively).

CONCLUSION

Our findings underscore the need for close monitoring of azole resistance in and echinocandin resistance in , and highlight age, sepsis, CVC insertion, and parenteral nutrition as key predictors of mortality in invasive infections.