Chang Marilene Rodrigues, Correia Flávia Patussi, Costa Leonora Correa, Xavier Paula Cristhina Niz, Palhares Durval Batista, Taira Deborah Ledesma, Paniago Anamaria Mello Miranda, Pontes Elenir Rose Jardim Cury, Machado Vanessa Escobar
Department of Pharmacy-Biochemistry, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil.
Rev Inst Med Trop Sao Paulo. 2008 Sep-Oct;50(5):265-8. doi: 10.1590/s0036-46652008000500003.
The incidence of Candida bloodstream infection has increased over the past years. In the Center-West region of Brazil, data on candidemia are scarce. This paper reports a retrospective analysis of 96 cases of Candida bloodstream infection at a Brazilian tertiary-care teaching hospital in the state of Mato Grosso do Sul, from January 1998 to December 2006. Demographic, clinical and laboratory data were collected from medical records and from the hospital's laboratory database. Patients' ages ranged from three days to 92 years, with 53 (55.2%) adults and 43 (44.8%) children. Of the latter, 25 (58.1%) were newborns. The risk conditions most often found were: long period of hospitalization, utilization of venous central catheter, and previous use of antibiotics. Fifty-eight (60.4%) patients died during the hospitalization period and eight (13.7%) of them died 30 days after the diagnosis of candidemia. Candida albicans (45.8%) was the most prevalent species, followed by C. parapsilosis (34.4%), C. tropicalis (14.6%) and C. glabrata (5.2%). This is the first report of Candida bloodstream infection in the state of Mato Grosso do Sul and it highlights the importance of considering the possibility of invasive Candida infection in patients exposed to risk factors, particularly among neonates and the elderly.
在过去几年中，念珠菌血流感染的发生率有所上升。在巴西中西部地区，关于念珠菌血症的数据稀缺。本文报告了对1998年1月至2006年12月期间南马托格罗索州一家巴西三级护理教学医院96例念珠菌血流感染病例的回顾性分析。从病历和医院实验室数据库中收集了人口统计学、临床和实验室数据。患者年龄从3天到92岁不等，其中53例（55.2%）为成年人，43例（44.8%）为儿童。在儿童患者中，25例（58.1%）为新生儿。最常发现的风险因素为：住院时间长、使用中心静脉导管以及既往使用过抗生素。58例（60.4%）患者在住院期间死亡，其中8例（13.7%）在念珠菌血症诊断后30天内死亡。白色念珠菌（45.8%）是最常见的菌种，其次是近平滑念珠菌（34.4%）、热带念珠菌（14.6%）和光滑念珠菌（5.2%）。这是南马托格罗索州念珠菌血流感染的首例报告，它强调了在有风险因素的患者中，尤其是新生儿和老年人中，考虑侵袭性念珠菌感染可能性的重要性。
