Zhang Songdi, Zhang Lijuan, Yusufu Aikedai, Hasimu Hadiliya, Wang Xiaodong, Abliz Paride
Department of Dermatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, People's Republic of China.
Infect Drug Resist. 2024 Apr 4;17:1345-1356. doi: 10.2147/IDR.S450933. eCollection 2024.
This study aims to investigate the clinical distribution characteristics and drug susceptibility profiles of invasive isolates in a tertiary hospital in Urumqi.
The examination was conducted on samples obtained from patients who were clinically diagnosed with invasive candidiasis in this hospital. A total of 109 strains of strains were identified through the use of internal transcribed spacer (ITS) sequencing and fungal cultivation methods.The clinical distribution of the strains was analyzed. Antifungal drug susceptibility tests were performed using the Sensititre YO10 fungal drug susceptibility plate based on the micro-broth dilution method.
had the highest percentage (51.38%) among 109 isolates, followed by (18.35%) and (15.60%). The isolates were predominantly found in the respiratory department (41.28%), intensive care unit (ICU) (31.19%), and infection department (9.17%).The results of drug susceptibility tests indicated that amphotericin B, 5-fluorocytosine, and echinocandins exhibited good in vitro antifungal activity, with a susceptibility rate of over 96%. However, the azoles demonstrated low antifungal activity, especially posaconazole and voriconazole, which had high resistance rates of 64.71% for and 70% for , respectively.
In our hospital, was identified as the primary causal agent of invasive candidiasis. In terms of in vitro antifungal activity, echinocandins, amphotericin B, and 5-fluorocytosine demonstrated efficacy against invasive infections. However, it was important to note that and exhibited low susceptibility to azoles.
本研究旨在调查乌鲁木齐某三级医院侵袭性分离株的临床分布特征及药敏情况。
对本院临床诊断为侵袭性念珠菌病患者的样本进行检测。通过内转录间隔区（ITS）测序和真菌培养方法共鉴定出109株菌株。分析菌株的临床分布情况。采用基于微量肉汤稀释法的Sensititre YO10真菌药敏平板进行抗真菌药敏试验。
在109株分离株中，[具体菌种1]所占比例最高（51.38%），其次是[具体菌种2]（18.35%）和[具体菌种3]（15.60%）。分离株主要分布在呼吸科（41.28%）、重症监护病房（ICU）（31.19%）和感染科（9.17%）。药敏试验结果表明，两性霉素B、5-氟胞嘧啶和棘白菌素类药物体外抗真菌活性良好，药敏率超过96%。然而，唑类药物抗真菌活性较低，尤其是泊沙康唑和伏立康唑，[具体菌种1]对其耐药率分别高达64.71%，[具体菌种2]对其耐药率高达70%。
在我院，[具体菌种1]被确定为侵袭性念珠菌病的主要病原体。就体外抗真菌活性而言，棘白菌素类药物、两性霉素B和5-氟胞嘧啶对侵袭性[具体菌种1]感染有效。然而，需要注意的是，[具体菌种1]和[具体菌种2]对唑类药物敏感性较低。
