Zhao Jian-Qiang, Wang Yan-Ming, Yang Yan-Long, Zeng Ying, Mei Li-Juan, Shi Yan-Ping, Tao Yan-Duo
Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, PR China.
Key Laboratory of Chemistry of Northwestern Plant Resources of CAS and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
Food Chem. 2017 Sep 1;230:117-124. doi: 10.1016/j.foodchem.2017.03.024. Epub 2017 Mar 6.
The young leaves and shoots of Sibiraea laevigata, known as "Liucha", are used as tea by Tibetans to improve digestion after meals. Long-term consumption of "Liucha" will cause weight loss. In present work, we reported on the isolation and NMR and chemical analysis-based elucidation of seven new sorbitol O-caffeic acid ester derivatives named sorbitol esters A-G (1-7) and eighteen known phenolic compounds from S. laevigata. All of the isolates were evaluated for their antioxidant and α-glucosidase inhibitory activities. Among them sorbitol ester A (1), sorbitol ester D (4), sorbitol ester F (6), sorbitol ester G (7), isoferulic acid (15), methyl caffeate (18), trans-p-hydroxycinnamic acid (19), and kaempferol 3-O-β-d-(6″-E-p-coumaroyl)-glucopyranoside (25) showed more potent α-glucosidase inhibitory activity than the clinical drug acarbose.
光滑山刺玫的幼叶和嫩枝被称为“柳茶”，藏族人将其用作茶饮以促进饭后消化。长期饮用“柳茶”会导致体重减轻。在本研究中，我们报道了从光滑山刺玫中分离出7种新的山梨醇O - 咖啡酸酯衍生物，命名为山梨醇酯A - G（1 - 7），以及18种已知的酚类化合物，并基于核磁共振和化学分析对其进行了结构解析。对所有分离物的抗氧化和α - 葡萄糖苷酶抑制活性进行了评估。其中，山梨醇酯A（1）、山梨醇酯D（4）、山梨醇酯F（6）、山梨醇酯G（7）、异阿魏酸（15）、咖啡酸甲酯（18）、反式对羟基肉桂酸（19）和山柰酚3 - O - β - d -（6″ - E - 对香豆酰） - 吡喃葡萄糖苷（25）表现出比临床药物阿卡波糖更强的α - 葡萄糖苷酶抑制活性。
