Castellaro M, Magliozzi R, Palombit A, Pitteri M, Silvestri E, Camera V, Montemezzi S, Pizzini F B, Bertoldo A, Reynolds R, Monaco S, Calabrese M
From the Department of Information Engineering (M. Castellaro, A.P., E.S., A.B.), University of Padova, Padova, Italy.
Neurology B (M. Castellaro, R.M., M.P., V.C., S.M., M. Calabrese), Department of Neurological, Biomedical and Movement Sciences, University of Verona, Verona, Italy.
AJNR Am J Neuroradiol. 2017 Jun;38(6):1087-1095. doi: 10.3174/ajnr.A5150. Epub 2017 Apr 13.
Quantitative susceptibility mapping has been used to characterize iron and myelin content in the deep gray matter of patients with multiple sclerosis. Our aim was to characterize the susceptibility mapping of cortical lesions in patients with MS and compare it with neuropathologic observations.
The pattern of microglial activation was studied in postmortem brain tissues from 16 patients with secondary-progressive MS and 5 age-matched controls. Thirty-six patients with MS underwent 3T MR imaging, including 3D double inversion recovery and 3D-echo-planar SWI.
Neuropathologic analysis revealed the presence of an intense band of microglia activation close to the pial membrane in subpial cortical lesions or to the WM border of leukocortical cortical lesions. The quantitative susceptibility mapping analysis revealed 131 cortical lesions classified as hyperintense; 33, as isointense; and 84, as hypointense. Quantitative susceptibility mapping hyperintensity edge found in the proximity of the pial surface or at the white matter/gray matter interface in some of the quantitative susceptibility mapping-hyperintense cortical lesions accurately mirrors the microglia activation observed in the neuropathology analysis.
Cortical lesion susceptibility maps are highly heterogeneous, even at individual levels. Quantitative susceptibility mapping hyperintensity edge found in proximity to the pial surface might be due to the subpial gradient of microglial activation.
定量磁化率成像已被用于表征多发性硬化症患者深部灰质中的铁和髓磷脂含量。我们的目的是表征多发性硬化症患者皮质病变的磁化率成像，并将其与神经病理学观察结果进行比较。
对16例继发进展型多发性硬化症患者和5例年龄匹配的对照者的死后脑组织进行小胶质细胞激活模式研究。36例多发性硬化症患者接受了3T磁共振成像检查，包括三维双反转恢复序列和三维回波平面磁敏感加权成像。
神经病理学分析显示，在软膜下皮质病变靠近软脑膜处或白质皮质病变的白质边界处存在一条强烈的小胶质细胞激活带。定量磁化率成像分析显示，131个皮质病变被分类为高信号；33个为等信号；84个为低信号。在一些定量磁化率成像高信号皮质病变中，在软脑膜表面附近或白质/灰质界面处发现的定量磁化率成像高信号边缘准确反映了神经病理学分析中观察到的小胶质细胞激活情况。
即使在个体水平上，皮质病变磁化率图也具有高度异质性。在软脑膜表面附近发现的定量磁化率成像高信号边缘可能是由于软膜下小胶质细胞激活梯度所致。
