Korf Eva Magdalena, Mölle Matthias, Born Jan, Ngo Hong-Viet V
Department of Neuroendocrinology, University of Lübeck, Lübeck, Germany.
Center of Brain, Behavior and Metabolism University of Lübeck, Lübeck, Germany.
Physiol Rep. 2017 Apr;5(7). doi: 10.14814/phy2.13239.
Slow wave activity (SWA, 0.5-4 Hz) represents the predominant EEG oscillatory activity during slow wave sleep (SWS). Its amplitude is considered in part a reflection of synaptic potentiation in cortical networks due to encoding of information during prior waking, with higher amplitude indicating stronger potentiation. Previous studies showed that increasing and diminishing specific motor behaviors produced corresponding changes in SWA in the respective motor cortical areas during subsequent SWS Here, we tested whether this relationship can be generalized to the visual system, that is, whether diminishing encoding of visual information likewise leads to a localized decrease in SWA over the visual cortex. Experiments were performed in healthy men whose eyes on two different days were or were not covered for 10.5 h before bedtime. The subject's EEG was recorded during sleep and, after sleep, visual evoked potentials (VEPs) were recorded. SWA during nonrapid eye movement sleep (NonREM sleep) was lower after blindfolding than after eyes open ( < 0.01). The decrease in SWA that was most consistent during the first 20 min of NonREM sleep, did not remain restricted to visual cortex regions, with changes over frontal and parietal cortical regions being even more pronounced. In the morning after sleep, the N75-P100 peak-to-peak-amplitude of the VEP was significantly diminished in the blindfolded condition. Our findings confirm a link between reduced wake encoding and diminished SWA during ensuing NonREM sleep, although this link appears not to be restricted to sensory cortical areas.
慢波活动（SWA，0.5 - 4赫兹）代表慢波睡眠（SWS）期间主要的脑电图振荡活动。其振幅部分被认为是由于先前清醒时信息编码导致皮质网络中突触增强的反映，振幅越高表明增强越强。先前的研究表明，增加和减少特定的运动行为会在随后的慢波睡眠期间在相应的运动皮质区域产生SWA的相应变化。在这里，我们测试了这种关系是否可以推广到视觉系统，即减少视觉信息编码是否同样会导致视觉皮质上SWA的局部降低。实验在健康男性中进行，在两个不同的日子里，他们在睡前10.5小时眼睛被覆盖或未被覆盖。在睡眠期间记录受试者的脑电图，并且在睡眠后记录视觉诱发电位（VEP）。蒙眼后非快速眼动睡眠（非快速眼动睡眠）期间的SWA低于睁眼后（<0.01）。在非快速眼动睡眠的前20分钟内最一致的SWA降低并不局限于视觉皮质区域，额叶和顶叶皮质区域的变化甚至更明显。在睡眠后的早晨，蒙眼条件下VEP的N75 - P100峰峰值振幅显著降低。我们的研究结果证实了减少清醒时的编码与随后非快速眼动睡眠期间SWA降低之间的联系，尽管这种联系似乎并不局限于感觉皮质区域。
