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专科干预与失代偿性心力衰竭患者改善的预后相关:多学科住院心力衰竭团队影响的评估

Specialist intervention is associated with improved patient outcomes in patients with decompensated heart failure: evaluation of the impact of a multidisciplinary inpatient heart failure team.

作者信息

Masters Jayne, Morton Geraint, Anton Isabel, Szymanski Jane, Greenwood Elizabeth, Grogono Joanna, Flett Andrew S, Cleland John G F, Cowburn Peter J

机构信息

Department of Cardiology, University Hospital Southampton, Southampton, UK.

Department of Cardiology, Portsmouth Hospitals NHS Trust, Portsmouth, UK.

出版信息

Open Heart. 2017 Mar 8;4(1):e000547. doi: 10.1136/openhrt-2016-000547. eCollection 2017.

Abstract

OBJECTIVE

The study aimed to evaluate the impact of a multidisciplinary inpatient heart failure team (HFT) on treatment, hospital readmissions and mortality of patients with decompensated heart failure (HF).

METHODS

A retrospective service evaluation was undertaken in a UK tertiary centre university hospital comparing 196 patients admitted with HF in the 6 months prior to the introduction of the HFT (pre-HFT) with all 211 patients seen by the HFT (post-HFT) during its first operational year.

RESULTS

There were no significant differences in patient baseline characteristics between the groups. Inpatient mortality (22% pre-HFT vs 6% post-HFT; p<0.0001) and 1-year mortality (43% pre-HFT vs 27% post-HFT; p=0.001) were significantly lower in the post-HFT cohort. Post-HFT patients were significantly more likely to be discharged on loop diuretics (84% vs 98%; p=<0.0001), ACE inhibitors (65% vs 76%; p=0.02), ACE inhibitors and/or angiotensin receptor blockers (83% vs 91%; p=0.02), and mineralocorticoid receptor antagonists (44% vs 68%; p<0.0001) pre-HFT versus post-HFT, respectively. There was no difference in discharge prescription rates of beta-blockers (59% pre-HFT vs 63% post-HFT; p=0.45). The mean length of stay (17±19 days pre-HFT vs 19±18 days post-HFT; p=0.06), 1-year all-cause readmission rates (46% pre-HFT vs 47% post-HFT; p=0.82) and HF readmission rates (28% pre-HFT vs 20% post-HFT; p=0.09) were not different between the groups.

CONCLUSIONS

The introduction of a specialist inpatient HFT was associated with improved patient outcome. Inpatient and 1-year mortality were significantly reduced. Improved use of evidence-based drug therapies, more intensive diuretic use and multidisciplinary care may contribute to these differences in outcome.

摘要

目的

本研究旨在评估多学科住院心力衰竭团队(HFT)对失代偿性心力衰竭(HF)患者的治疗、再入院率及死亡率的影响。

方法

在英国一家三级中心大学医院进行了一项回顾性服务评估,比较了HFT引入前6个月内收治的196例HF患者(HFT前)与HFT运营第一年诊治的所有211例患者(HFT后)。

结果

两组患者的基线特征无显著差异。HFT后队列的住院死亡率(HFT前为22%,HFT后为6%;p<0.0001)和1年死亡率(HFT前为43%,HFT后为27%;p=0.001)显著降低。HFT后患者出院时使用袢利尿剂(84%对98%;p<0.0001)、ACE抑制剂(65%对76%;p=0.02)、ACE抑制剂和/或血管紧张素受体阻滞剂(83%对91%;p=0.02)以及盐皮质激素受体拮抗剂(44%对68%;p<0.0001)的可能性分别显著高于HFT前。β受体阻滞剂的出院处方率无差异(HFT前为59%,HFT后为63%;p=0.45)。两组的平均住院时间(HFT前为17±19天,HFT后为19±18天;p=0.06)、1年全因再入院率(HFT前为46%,HFT后为47%;p=0.82)和HF再入院率(HFT前为28%,HFT后为20%;p=0.09)无差异。

结论

引入专科住院HFT与改善患者预后相关。住院死亡率和1年死亡率显著降低。循证药物治疗的更好应用、更强化的利尿剂使用和多学科护理可能导致这些预后差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9a5/5384462/63b1dc775f6f/openhrt-2016-000547f01.jpg

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