Hornicek F J, Reese D H, Lo H K, Malinin T I, Malinin G I
Department of Surgery, University of Miami, School of Medicine, FL 33101.
Biochem Biophys Res Commun. 1988 Jul 29;154(2):606-12. doi: 10.1016/0006-291x(88)90182-9.
The blastogenic transformation of lymphocytes by periodic acid was investigated to determine if blastogenesis induced by this mitogen was preceded by phosphoinositide turnover as previously shown for the lectins. Although periodate oxidation stimulated nucleic acid synthesis and interleukin-2 production, no changes in phosphoinositide turnover could be detected when compared to control lymphocyte cultures. These data indicate that increased phosphoinositide turnover is not an absolute prerequisite for lymphocyte proliferation.
研究了高碘酸对淋巴细胞的致有丝分裂转化作用，以确定这种促有丝分裂原诱导的细胞增殖是否如先前针对凝集素所显示的那样，在磷酸肌醇转换之前发生。尽管高碘酸盐氧化刺激了核酸合成和白细胞介素-2的产生，但与对照淋巴细胞培养物相比，未检测到磷酸肌醇转换的变化。这些数据表明，磷酸肌醇转换增加不是淋巴细胞增殖的绝对先决条件。
