Guenounou M, Agneray J
Immunology. 1979 May;37(1):53-9.
Normal mouse spleen cells treated with sodium periodate for 10 min at 4 degrees are stimulated to undergo blastogenesis and to incorporate thymidine. In contrast, periodate treatment does not stimulate DNA synthesis in nude mice spleen cells. The effect of such treatment on the antibody response in vitro induced by sheep red blood cells (SRBC) and by trinitrophenyl polyacrylamide (TNP-PAA), a T-independent antigen has been evaluated. Periodic-induced proliferation is accompanied by a marked inhibition of the immune response to both of these antigens in normal mouse spleen cells. Mild oxidation of nude cells with periodate markedly enhances their anti-TNP response elicited by TNP-PAA. The data suggest that periodate-induced immune suppression is associated with T lymphocytes. Furthermore, periodate-treated cells are capable of suppressing the in vitro antibody response of untreated normal cells.
在4℃下用高碘酸钠处理10分钟的正常小鼠脾细胞会被刺激发生母细胞化并掺入胸腺嘧啶核苷。相比之下，高碘酸钠处理不会刺激裸鼠脾细胞中的DNA合成。已经评估了这种处理对由绵羊红细胞（SRBC）和三硝基苯基聚丙烯酰胺（TNP-PAA，一种非T细胞依赖性抗原）在体外诱导的抗体反应的影响。高碘酸钠诱导的增殖伴随着正常小鼠脾细胞对这两种抗原的免疫反应的显著抑制。用高碘酸钠对裸细胞进行轻度氧化可显著增强由TNP-PAA引发的它们的抗TNP反应。数据表明，高碘酸钠诱导的免疫抑制与T淋巴细胞有关。此外，经高碘酸钠处理的细胞能够抑制未处理的正常细胞的体外抗体反应。
