Goodarzi Zahra, Ismail Zahinoor
Department of Medicine, Section of Geriatric Medicine (ZG), Department of Psychiatry (ZI), and Department of Clinical Neurosciences (ZI), University of Calgary and Alberta Health Services; and the Hotchkiss Brain Institute (ZI) and The Mathison Centre for Mental Health Research and Education (ZI), University of Calgary, Canada.
Neurol Clin Pract. 2017 Apr;7(2):128-140. doi: 10.1212/CPJ.0000000000000351.
To review the available evidence for the detection and management of depression in Parkinson disease (PD) and dementia.
Depression is a common comorbidity in those with PD or dementia, and leads to increased morbidity. There are several available and accurate tools for the detection of depression in PD (e.g., Geriatric Depression Scale) and dementia (e.g., Cornell Scale for Depression in Dementia). Treatment of depression depends on patient preference, severity of depression, comorbidities, and available resources. Despite variable evidence, the use of nonpharmacologic strategies to manage depression is suggested. Pharmacologic management is guided by modest evidence in PD and dementia, but also informed by the management of late-life depression (LLD).
There is evidence to guide the diagnosis and management of depression in PD or dementia. However, more research is required in this field to better inform clinical decision-making.
综述帕金森病（PD）和痴呆症中抑郁症检测与管理的现有证据。
抑郁症是PD或痴呆症患者常见的合并症，会导致发病率增加。有几种可用且准确的工具可用于检测PD（如老年抑郁量表）和痴呆症（如康奈尔痴呆抑郁量表）中的抑郁症。抑郁症的治疗取决于患者偏好、抑郁严重程度、合并症和可用资源。尽管证据不一，但建议采用非药物策略来管理抑郁症。药物管理在PD和痴呆症中有适度证据指导，但也受老年期抑郁症（LLD）管理的影响。
有证据可指导PD或痴呆症中抑郁症的诊断和管理。然而，该领域需要更多研究以更好地为临床决策提供依据。
