Nassif Daniel Venturino, Pereira João Santos
Universidade do Estado do Rio de Janeiro, Hospital Universitário Pedro Ernesto, Departamento de Neurologia, Rio de Janeiro RJ, Brazil.
Dement Neuropsychol. 2022 Apr-Jun;16(2):237-242. doi: 10.1590/1980-5764-DN-2021-0083. Epub 2022 May 13.
Fatigue is a non-motor symptom of high prevalence in Parkinson's disease (PD); however, it is still unknown and neglected by health professionals.
This study aimed to demonstrate the prevalence of fatigue in patients with PD after excluding confounding factors, as well as its correlation with clinical and demographic data, and to find its negative impact on the quality of life of these patients.
A cross-sectional study was carried out with 237 randomly selected patients. According to inclusion and exclusion criteria, we selected 53 patients, who were then submitted to the Fatigue Severity Scale. Clinical and demographic data were also analyzed, comparing them between patients with and without fatigue.
We identified fatigue in 21 (39.62%) patients. Patients with and without fatigue had similar mean scores on the UPDRS-III (p=0.36), equivalent daily dose of levodopa (p=0.94), mean disease duration (p=0.43), and mean age (p<0.99). Fatigued patients had worse quality of life scores (PDQ-39) (p=0.00). We did not observe a correlation between fatigue, duration of illness (r=0.11; p=0.43), age (r=0.00; p=0.99), and UPDRS-III (r=0.20; p=0.16).
Fatigue is a highly prevalent and independent symptom of PD. There is no correlation between age, mean duration of disease, motor impairment, and its presence. It has a negative impact on quality of life.
疲劳是帕金森病（PD）中一种高患病率的非运动症状；然而，它仍然不为人知且被健康专业人员忽视。
本研究旨在证明排除混杂因素后PD患者中疲劳的患病率，以及其与临床和人口统计学数据的相关性，并找出其对这些患者生活质量的负面影响。
对237名随机选择的患者进行了横断面研究。根据纳入和排除标准，我们选择了53名患者，然后让他们接受疲劳严重程度量表评估。还分析了临床和人口统计学数据，对有疲劳和无疲劳的患者进行比较。
我们在21名（39.62%）患者中发现了疲劳。有疲劳和无疲劳的患者在统一帕金森病评定量表第三部分（UPDRS-III）上的平均得分相似（p = 0.36），左旋多巴的日均剂量相当（p = 0.94），平均病程（p = 0.43）和平均年龄（p < 0.99）。疲劳患者的生活质量得分（PDQ-39）更差（p = 0.00）。我们未观察到疲劳与病程（r = 0.11；p = 0.43）、年龄（r = 0.00；p = 0.99）和UPDRS-III（r = 0.20；p = 0.16）之间存在相关性。
疲劳是PD一种高度普遍且独立的症状。年龄、平均病程、运动障碍与其存在之间无相关性。它对生活质量有负面影响。
