LaHoste G J, Mormède P, Rivet J M, Le Moal M
Laboratoire de Psychobiologie des Comportements Adaptatifs, I.N.S.E.R.M. Unité 259, Bordeaux, France.
Brain Res. 1988 Jun 21;453(1-2):381-4. doi: 10.1016/0006-8993(88)90183-7.
With repeated administrations, rodents become increasingly sensitive to the stimulant properties of amphetamine, a phenomenon termed sensitization. Rats differentiated on the basis of their preferred direction of rotation following peripheral administration of amphetamine were found to differ in their sensitization to amphetamine in two different behavioral paradigms. Rats which displayed leftward rotational biases developed greater sensitization and greater hormonal response to stress following sensitization.
随着反复给药，啮齿动物对苯丙胺的兴奋特性变得越来越敏感，这种现象称为敏化。发现在外周给予苯丙胺后根据其偏好的旋转方向区分的大鼠，在两种不同的行为范式中对苯丙胺的敏化程度有所不同。表现出左旋偏向的大鼠在敏化后对压力产生了更大的敏化和更大的激素反应。
