Turner Robert M, Morgan Todd M, Jacobs Bruce L
Department of Urology, University of Pittsburgh Medical Center, Mercy Professional Building, 1350 Centre Avenue, Suite G100A, Pittsburgh, PA 15219, USA.
Department of Urology, University of Michigan, 1500 E. Medical Center Drive, CCC 7308, Ann Arbor, MI 48109, USA.
Urol Clin North Am. 2017 May;44(2):147-154. doi: 10.1016/j.ucl.2016.12.001. Epub 2017 Mar 14.
The incidence of kidney cancer has steadily increased over recent decades, with most new cases now found when lesions are asymptomatic and small. This downward stage migration relates to the increasing use of abdominal imaging. Three public health epidemics-smoking, hypertension, and obesity-also play roles in the increase. Treatment mirrors the rise in incidence, with increasing interest in nephron-sparing therapies. Despite earlier detection and increasing treatment, the mortality rate has not decreased. This treatment disconnect phenomenon highlights the need to decrease unnecessary treatment of indolent tumors and address modifiable risk factors to reduce incidence and mortality.
近几十年来,肾癌的发病率稳步上升,现在大多数新病例是在病变无症状且较小的时候发现的。这种分期下移与腹部影像学检查的使用增加有关。吸烟、高血压和肥胖这三种公共卫生流行病也在发病率上升中起作用。治疗情况与发病率的上升相呼应,对保留肾单位疗法的兴趣日益增加。尽管检测更早且治疗增加,但死亡率并未下降。这种治疗脱节现象凸显了减少对惰性肿瘤的不必要治疗以及解决可改变的风险因素以降低发病率和死亡率的必要性。