Wang Tingliang, Zhu Lian, Pei Ming
Stem Cell and Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, Morgantown, WV, USA.
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
F1000Res. 2017 Mar 17;6:291. doi: 10.12688/f1000research.10280.1. eCollection 2017.
For decades, researchers have been fascinated by the strategy of using cell therapy for bone defects; some progress in the field has been made. Owing to its ample supply and easy access, skin, the largest organ in the body, has gained attention as a potential source of stem cells. Despite extensive applications in skin and nerve regeneration, an increasing number of reports indicate its potential use in bone tissue engineering and regeneration. Unfortunately, few review articles are available to outline current research efforts in skin-based osteogenesis. This review first summarizes the latest findings on stem cells or progenitors in skin and their niches and then discusses the strategies of skin cell-based osteogenesis. We hope this article elucidates this topic and generates new ideas for future studies.
几十年来，研究人员一直对利用细胞疗法治疗骨缺损的策略着迷；该领域已取得了一些进展。皮肤作为人体最大的器官，因其供应充足且易于获取，已成为一种潜在的干细胞来源而受到关注。尽管在皮肤和神经再生方面有广泛应用，但越来越多的报告表明其在骨组织工程和再生中的潜在用途。不幸的是，很少有综述文章概述基于皮肤的骨生成的当前研究成果。本综述首先总结了皮肤中干细胞或祖细胞及其微环境的最新发现，然后讨论了基于皮肤细胞的骨生成策略。我们希望本文能阐明这一主题，并为未来的研究产生新的思路。
