Al Salloum H, Saunier J, Dazzi A, Vigneron J, Etcheberry A, Marlière C, Aymes-Chodur C, Herry J M, Bernard M, Jubeli E, Yagoubi N
IFR 141, EA 401, UFR de Pharmacie, Univ. Paris Sud - Université Paris-Saclay, 92290 Chatenay Malabry, France.
IFR 141, EA 401, UFR de Pharmacie, Univ. Paris Sud - Université Paris-Saclay, 92290 Chatenay Malabry, France.
Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:317-334. doi: 10.1016/j.msec.2017.02.057. Epub 2017 Feb 16.
Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.
采用光谱、色谱和显微镜技术对由增塑聚氯乙烯制成的商用输液管和血液储存装置（输液管、血袋和血小板袋）进行分析，以识别和量化添加到聚合物中的添加剂（润滑剂、热稳定剂、增塑剂），并证明它们在装置表面的析出情况。对于所有样品，在其表面均观察到沉积物，但形态各异。乙烯双酰胺润滑剂和金属硬脂酸盐稳定剂与这些层的形成有关。与水性介质接触时，这些不溶性沉积物会受到破坏，这表明输注溶液可能存在颗粒污染。
