Torres E, Fombuena V, Vallés-Lluch A, Ellingham T
Instituto de Tecnología de Materiales (ITM), Universitat Politècnica de València (UPV), Plaza Ferrándiz y Carbonell, s/n, 03801 Alcoy, Spain; Centre for Biomaterials and Tissue Engineering, Universitat Politècnica de València, Camí de Vera, s/n, 46022, Valencia, Spain.
Instituto de Tecnología de Materiales (ITM), Universitat Politècnica de València (UPV), Plaza Ferrándiz y Carbonell, s/n, 03801 Alcoy, Spain.
Mater Sci Eng C Mater Biol Appl. 2017 Jun 1;75:418-424. doi: 10.1016/j.msec.2017.02.087. Epub 2017 Feb 20.
Hydroxyapatite (HA) and Halloysite nanotubes (HNTs) percentages have been optimized in Polycaprolactone (PCL) polymeric matrices to improve mechanical, thermal and biological properties of the composites, thus, to be applied in bone tissue engineering or as fixation plates. Addition of HA guarantees a proper compatibility with human bone due to its osteoconductive and osteoinductive properties, facilitating bone regeneration in tissue engineering applications. Addition of HNTs ensures the presence of tubular structures for subsequent drug loading in their lumen, of molecules such as curcumin, acting as controlled drug delivery systems. The addition of 20% of HA and different amounts of HNTs leads to a substantial improvement in mechanical properties with values of flexural strength up to 40% over raw PCL, with an increase in degradation temperature. DMA analyses showed stability in mechanical and thermal properties, having as a result a potential composite to be used as tissue engineering scaffold or resorbable fixation plate.
羟基磷灰石（HA）和埃洛石纳米管（HNTs）的比例已在聚己内酯（PCL）聚合物基体中得到优化，以改善复合材料的机械、热学和生物学性能，从而应用于骨组织工程或用作固定板。由于HA具有骨传导性和骨诱导性，添加HA可确保与人体骨骼具有适当的相容性，有助于组织工程应用中的骨再生。添加HNTs可确保存在管状结构，以便随后在其管腔中负载姜黄素等分子，作为控释药物递送系统。添加20%的HA和不同量的HNTs可显著改善机械性能，弯曲强度值比原始PCL提高了40%，同时降解温度也有所升高。动态热机械分析（DMA）表明其机械和热性能具有稳定性，因此该复合材料有望用作组织工程支架或可吸收固定板。
