Azadpour Behnam, Kashanian Faezeh, Habibi-Rezaei Mehran, Seyyed Ebrahimi Seyyed Ali, Yazdanpanah Roozbeh, Lalegani Zahra, Hamawandi Bejan
Advanced Magnetic Materials Research Center, School of Metallurgy and Materials, College of Engineering, University of Tehran, Tehran 111554563, Iran.
School of Biology, College of Science, University of Tehran, Tehran 111554563, Iran.
Materials (Basel). 2022 Dec 8;15(24):8762. doi: 10.3390/ma15248762.
In this study, L-arginine (Arg) modified magnetite (FeO) nanoparticles (RMNPs) were firstly synthesized through a one-step co-precipitation method, and then these aminated nanoparticles (NPs) were, again, coated by pre-oxidized dextran (Dext), in which aldehyde groups (DextCHO) have been introduced on the polymer chain successfully via a strong chemical linkage. Arg, an amino acid, acts as a mediator to link the Dext to a magnetic core. The as-synthesized Arg-modified and Dext-coated arginine modified FeO NPs were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transformation infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM). Both synthesized samples, XRD pattern and FT-IR spectra proved that the core is magnetite. FT-IR confirmed that the chemical bonds of Arg and Dext both exist in the samples. SEM images showed that the NPs are spherical and have an acceptable distribution size, and the VSM analysis indicated the superparamagnetic behavior of samples. The saturation magnetization was decreased after Dext coating, which confirms successive coating RMNPs with Text. In addition, the TGA analysis demonstrated that the prepared magnetic nanocomposites underwent various weight loss levels, which admitted the modification of magnetic cores with Arg and further coating with Dext.
在本研究中，首先通过一步共沉淀法合成了L-精氨酸（Arg）修饰的磁铁矿（FeO）纳米颗粒（RMNPs），然后这些胺化纳米颗粒（NPs）再次用预氧化葡聚糖（Dext）包覆，其中醛基（DextCHO）已通过强化学键成功引入到聚合物链上。氨基酸Arg作为介质将Dext连接到磁核上。通过扫描电子显微镜（SEM）、X射线衍射（XRD）、傅里叶变换红外光谱（FT-IR）、热重分析（TGA）和振动样品磁强计（VSM）对合成的Arg修饰和Dext包覆的精氨酸修饰FeO NPs进行了表征。两种合成样品的XRD图谱和FT-IR光谱均证明其核心为磁铁矿。FT-IR证实样品中同时存在Arg和Dext的化学键。SEM图像显示NPs呈球形且具有可接受的粒径分布，VSM分析表明样品具有超顺磁行为。Dext包覆后饱和磁化强度降低，这证实了RMNPs被Text连续包覆。此外，TGA分析表明制备的磁性纳米复合材料经历了不同程度的失重，这证实了磁核被Arg修饰并进一步被Dext包覆。
