IS介导的黏菌素抗性基因转移的研究
Study of IS-Mediated Mobilization of the Colistin Resistance Gene .
作者信息
Poirel Laurent, Kieffer Nicolas, Nordmann Patrice
机构信息
Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Fribourg, Switzerland
French INSERM European Unit, University of Fribourg (LEA-IAME), Fribourg, Switzerland.
出版信息
Antimicrob Agents Chemother. 2017 Jun 27;61(7). doi: 10.1128/AAC.00127-17. Print 2017 Jul.
Abstract
The plasmid-mediated gene encodes a phosphoethanolamine transferase that confers resistance to polymyxins. The gene is associated with insertion sequence IS (IS family). mobilization assays demonstrated the functionality of the composite transposon structure IS-IS Transposition generated a 2-bp duplication and occurred in AT-rich DNA regions. This is the first report demonstrating the mobility of the gene by transposition.
摘要
质粒介导的基因编码一种磷酸乙醇胺转移酶，该酶赋予对多粘菌素的抗性。该基因与插入序列IS（IS家族）相关。移动分析证明了复合转座子结构IS-IS的功能。转座产生了一个2 bp的重复，并且发生在富含AT的DNA区域。这是首次证明该基因通过转座实现移动性的报告。
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