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黑色素化真菌致硬膜外脓肿:一项诊断与治疗挑战。

Melanized fungus as an Epidural abscess: A diagnostic and therapeutic challenge.

作者信息

Shrivastava Adesh, Tadepalli Karuna, Goel Garima, Gupta Kajal, Kumar Gupta Pradeep

机构信息

Department of Neurosurgery, AIIMS Bhopal, Bhopal 462024, MP, India.

Department of Microbiology, AIIMS Bhopal, Bhopal 462024, MP, India.

出版信息

Med Mycol Case Rep. 2017 Apr 6;16:20-24. doi: 10.1016/j.mmcr.2017.04.001. eCollection 2017 Jun.

DOI:10.1016/j.mmcr.2017.04.001
PMID:28417063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5389101/
Abstract

a dematiaceous fungus is ubiquitously found in soil around the world. We report an epidural abscess due to in a 48 years male farmer who underwent decompressive laminectomy as primary modality of treatment followed by isolation, identification and confirmation of the isolate from tissue by ITS sequencing. Antifungal therapy with voriconazole and amphotericin B for 3 and 2 weeks respectively improved patient's condition and is presently on regular follow up with no sequelae since last 7 months.

摘要

一种暗色真菌在世界各地的土壤中普遍存在。我们报告了一例48岁男性农民因[此处原文缺失真菌名称]导致的硬膜外脓肿,该患者接受了减压性椎板切除术作为主要治疗方式,随后通过ITS测序从组织中分离、鉴定并确认了该分离株。分别使用伏立康唑和两性霉素B进行3周和2周的抗真菌治疗改善了患者的病情,目前正在定期随访,自过去7个月以来无后遗症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d581/5389101/b9495bfa05ae/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d581/5389101/c49f0d142801/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d581/5389101/a9563ccb28a7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d581/5389101/b9495bfa05ae/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d581/5389101/c49f0d142801/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d581/5389101/a9563ccb28a7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d581/5389101/b9495bfa05ae/gr3.jpg

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Indian Dermatol Online J. 2015 Sep-Oct;6(5):359-61. doi: 10.4103/2229-5178.164468.
2
Novel Curvularia species from clinical specimens.来自临床标本的新型弯孢霉属物种。
Persoonia. 2014 Dec;33:48-60. doi: 10.3767/003158514X683538. Epub 2014 Jul 29.
3
Identification of Curvularia lunata by polymerase chain reaction in a case of fungal endophthalmitis.聚合酶链反应在一例真菌性眼内炎中鉴定新月弯孢霉。
Response of Human Neutrophil Granulocytes to the Hyphae of the Emerging Fungal Pathogen .
人类中性粒细胞对新兴真菌病原体菌丝的反应
Pathogens. 2020 Mar 21;9(3):235. doi: 10.3390/pathogens9030235.
Med Mycol Case Rep. 2013 Aug 9;2:137-40. doi: 10.1016/j.mmcr.2013.07.001.
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Curvularia abscess of the brainstem.脑桥弯孢菌脓肿。
World Neurosurg. 2014 Jul-Aug;82(1-2):241.e9-13. doi: 10.1016/j.wneu.2013.07.014. Epub 2013 Jul 23.
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Melanized fungi in human disease.人类疾病中的黑化真菌。
Clin Microbiol Rev. 2010 Oct;23(4):884-928. doi: 10.1128/CMR.00019-10.
6
Epidemiology of central nervous system mycoses.中枢神经系统真菌病的流行病学
Neurol India. 2007 Jul-Sep;55(3):191-7. doi: 10.4103/0028-3886.35679.
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Spinal epidural abscess.脊柱硬膜外脓肿
N Engl J Med. 2006 Nov 9;355(19):2012-20. doi: 10.1056/NEJMra055111.
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Fatal cerebral phaeohyphomycosis due to Curvularia lunata in an immunocompetent patient.免疫功能正常患者发生由新月弯孢霉引起的致命性脑暗色丝孢霉病。
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Arch Intern Med. 1979 Aug;139(8):940-1.