血小板衍生生长因子的结构与功能方面
Structural and functional aspects of platelet-derived growth factor.
作者信息
Heldin C H, Hammacher A, Nistér M, Westermark B
机构信息
Ludwig Institute for Cancer Research, Uppsala, Sweden.
出版信息
Br J Cancer. 1988 Jun;57(6):591-3. doi: 10.1038/bjc.1988.134.
Abstract
The finding that PDGF production is common in normal as well as transformed cells indicate that PDGF has a function in autocrine and paracrine stimulation of cells in several physiological and pathological conditions. The expression of mRNA for the two chains of PDGF are independently regulated. The fact that the different dimeric forms of PDGF have different functional effects, indicate that the cellular response to PDGF may be more complex than previously thought, and may involve binding to more than one receptor. The cellular effects ascribed to PDGF, growth stimulation, ruffling and chemotaxis, seems to be mainly associated with B chain containing dimers. The function of PDGF-AA remains to be elucidated.
摘要
血小板衍生生长因子（PDGF）在正常细胞和转化细胞中均普遍产生，这一发现表明PDGF在多种生理和病理条件下对细胞的自分泌和旁分泌刺激中具有功能。PDGF两条链的mRNA表达是独立调节的。不同二聚体形式的PDGF具有不同功能效应，这一事实表明细胞对PDGF的反应可能比之前认为的更为复杂，且可能涉及与不止一种受体结合。归因于PDGF的细胞效应，如生长刺激、微丝边缘波动和趋化性，似乎主要与含B链的二聚体有关。PDGF-AA的功能仍有待阐明。
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