Bowen-Pope D F, Ross R
Clin Endocrinol Metab. 1984 Mar;13(1):191-205. doi: 10.1016/s0300-595x(84)80013-4.
Platelet-derived growth factor (PDGF) is a basic (pI congruent to 10) 30 000 molecular weight protein circulating in normal blood sequestered within the platelet alpha-granules. It binds with high affinity (Kd = 10(-11) M) to a specific cell-surface receptor found on many connective tissue cell types in culture. It is active in stimulating the metabolism and multiplication of connective tissue cells at very low concentrations (ED50 = 10(-11) M). It is likely that PDGF is released from platelets at sites of vascular damage and that it contributes toward the cell proliferation and connective tissue formation seen in healing wounds and in arteriosclerotic lesions. PDGF which does not bind to responsive cells at the wound site is largely inactivated by a plasma binding protein and is rapidly cleared from the circulation.
血小板衍生生长因子（PDGF）是一种碱性蛋白质（等电点约为10），分子量为30000，在正常血液中循环，储存于血小板α颗粒内。它以高亲和力（解离常数Kd = 10⁻¹¹M）与培养的多种结缔组织细胞类型上发现的特定细胞表面受体结合。在极低浓度（半数有效剂量ED50 = 10⁻¹¹M）下，它就能激活结缔组织细胞的代谢和增殖。PDGF很可能在血管损伤部位从血小板中释放出来，并促进愈合伤口和动脉粥样硬化病变中所见的细胞增殖和结缔组织形成。未与伤口部位反应性细胞结合的PDGF在很大程度上会被血浆结合蛋白灭活，并迅速从循环中清除。
