Gvozdanovic Geraldine A, Stämpfli Philipp, Seifritz Erich, Rasch Björn
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich, Switzerland.
Division of Biopsychology, Institute of Psychology, University of Zürich, Zürich, Switzerland.
Hum Brain Mapp. 2017 Jul;38(7):3592-3602. doi: 10.1002/hbm.23613. Epub 2017 Apr 17.
Traumatic memories such as intrusions and flashbacks play a major role in the development and maintenance of post-traumatic stress disorder (PTSD). A thorough understanding of the neural mechanisms underlying traumatic memories is indispensable for precise diagnosis, for personalized treatment and prevention. In particular, the identification of early neural predictor variables for intrusion development shortly after trauma exposure requires detailed investigation.
Here, we examined the neural correlates of early experimental trauma memory retrieval in a traumatic film paradigm in 42 young healthy females, using both implicit and explicit retrieval tasks.
We show that implicit experimental trauma retrieval specifically involved the retrosplenial cortex and the anterior cingulate cortex (ACC), while both retrieval tasks resulted in trauma-related activity in the posterior cingulate cortex (PCC) and the precuneus. Importantly, neural activity early after experimental trauma exposure predicted later intrusion development, with independent contributions from activity in the retrosplenial cortex (implicit retrieval) and the PCC (explicit retrieval). Additional analyses revealed a stronger connectivity between the bilateral amygdala and the supplementary motor area, precentral and paracentral lobule for the control group compared to the experimental trauma group.
Our study gives new insights in the neural correlates of experimental trauma memory retrieval and their predictive value for subsequent symptom development. Our results could provide the basis for personalized early treatment and prevention of PTSD. Hum Brain Mapp, 2017. © 2017 Wiley Periodicals, Inc. Hum Brain Mapp 38:3592-3602, 2017. © 2017 Wiley Periodicals, Inc.
诸如侵入性记忆和闪回等创伤性记忆在创伤后应激障碍（PTSD）的发生和维持中起主要作用。深入了解创伤性记忆背后的神经机制对于精确诊断、个性化治疗和预防不可或缺。特别是，创伤暴露后不久侵入性记忆发展的早期神经预测变量的识别需要详细研究。
在此，我们在42名年轻健康女性的创伤性电影范式中，使用内隐和外显检索任务，研究了早期实验性创伤记忆检索的神经相关性。
我们发现，内隐实验性创伤检索特别涉及压后皮质和前扣带回皮质（ACC），而两种检索任务均导致后扣带回皮质（PCC）和楔前叶出现与创伤相关的活动。重要的是，实验性创伤暴露后早期的神经活动预测了后期侵入性记忆的发展，压后皮质（内隐检索）和PCC（外显检索）的活动有独立贡献。额外分析显示，与实验性创伤组相比，对照组双侧杏仁核与辅助运动区、中央前回和中央旁小叶之间的连接更强。
我们的研究为实验性创伤记忆检索的神经相关性及其对后续症状发展的预测价值提供了新见解。我们的结果可为PTSD的个性化早期治疗和预防提供依据。《人类大脑图谱》，2017年。©2017威利期刊公司。《人类大脑图谱》38:3592 - 3602，2017年。©2017威利期刊公司。
