在奥地利蒂罗尔州引入乳腺钼靶筛查项目后晚期乳腺癌病例数减少。

Reduction in advanced breast cancer after introduction of a mammography screening program in Tyrol/Austria.

作者信息

Oberaigner W, Geiger-Gritsch Sabine, Edlinger M, Daniaux M, Knapp R, Hubalek M, Siebert U, Marth C, Buchberger W

机构信息

Department of Clinical Epidemiology of the Tirol Kliniken Ltd., Cancer Registry of Tyrol, Innsbruck, Austria; Institute of Public Health, Medical Decision Making and Health Technology Assessment, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT - University for Health Sciences, Medical Informatics and Technology, Hall i.T., Austria.

出版信息

Breast. 2017 Jun;33:178-182. doi: 10.1016/j.breast.2017.04.002. Epub 2017 Apr 15.

DOI:10.1016/j.breast.2017.04.002

PMID:28419909

Abstract

BACKGROUND

We analysed all female breast cancer (BC) cases in Tyrol/Austria regarding the shift in cancer characteristics, especially the shift in advanced BC, for the group exposed to screening as compared to the group unexposed to screening.

METHODS

The analysis was based on all BC cases diagnosed in women aged 40-69 years, resident in Tyrol, and diagnosed between 2009 and 2013. The data were linked to the Tyrolean mammography screening programme database to classify BC cases as "exposed to screening" or "unexposed to screening". Age-adjusted relative risks (RR) were estimated by relating the exposed to the unexposed group.

RESULTS

In a total of about 145,000 women aged 40-69 years living in Tyrol during the study period, 1475 invasive BC cases were registered. We estimated an age-adjusted relative risk (RR) for tumour size ≥ 21 mm of 0.72 (95% confidence interval (CI) 0.60 to 0.86), for metastatic BC of 0.27 (95% CI 0.17 to 0.46) and for advanced BC of 0.83 (95% CI 0.71 to 0.96), each comparing those exposed to those unexposed to screening, respectively.

CONCLUSION

In our population-based registry analysis we observed that participation in the mammography screening programme in Tyrol is associated with a 28% decrease in risk for BC cases with tumour size ≥ 21 mm and a 17% decrease in risk for advanced BC. We therefore expect the Tyrolean mammography programme to show a reduction in BC mortality.

摘要

背景

我们分析了奥地利蒂罗尔州所有女性乳腺癌（BC）病例，以研究接受筛查组与未接受筛查组相比癌症特征的变化，尤其是晚期乳腺癌的变化。

方法

该分析基于2009年至2013年间居住在蒂罗尔州、年龄在40 - 69岁之间被诊断为BC的所有病例。数据与蒂罗尔州乳腺钼靶筛查项目数据库相关联，以将BC病例分类为“接受筛查”或“未接受筛查”。通过将暴露组与未暴露组进行比较，估计年龄调整后的相对风险（RR）。

结果

在研究期间，共有约145,000名年龄在40 - 69岁之间居住在蒂罗尔州的女性，登记了1475例浸润性BC病例。我们估计，对于肿瘤大小≥21mm的病例，年龄调整后的相对风险（RR）为0.72（95%置信区间（CI）0.60至0.86）；对于转移性BC，RR为0.27（95%CI 0.17至0.46）；对于晚期BC，RR为0.83（95%CI 0.71至0.96），每次分别比较接受筛查者与未接受筛查者。