Steponaviciene Laura, Briediene Ruta, Vanseviciute Rasa, Smailyte Giedre
1 Laboratory of cancer epidemiology, National Cancer Institute, Vilnius, Lithuania.
2 Department of Public Health, Institute of Health Sciences of the Faculty of Medicine of Vilnius University, Vilnius, Lithuania.
Cancer Control. 2019 Jan-Dec;26(1):1073274818821096. doi: 10.1177/1073274818821096.
: The aim of this study was to analyze the incidence trends of localized and advanced breast cancer (BC) before and during the implementation of the mammography screening program (MSP) in Lithuania.
: The study period was divided into 2 intervals: the prescreening period (1998-2005) and implementation period (2006-2012). Analysis was performed for 3 age-groups: 0 to 49 years, 50 to 69 (target population), and older than 70.
: In all age-groups, the incidence of localized BC has shown a steady increase, while the incidence of advanced stage BC has decreased. In the target population, during the study period, the stage I BC incidence increased statistically significantly by 10.3% per year (from 3.3 per 100 000 in 1998 to 12.2 per 100 000 in 2012). The increase in localized BC was faster in the period before the implementation of the MSP than during the implementation in 2006 to 2012 (10.3% and 5.7%). A slightly statistically significant decrease was observed for advanced BC during the study period (-1.1% per year), while during the implementation of the MSP, significant changes were not seen.
: The results of our study indicate that the implementation of the MSP in Lithuania did not significantly influence trends of localized and advanced BC. Changes observed during the study period, including the prescreening and screening introduction periods, may reflect the general trends in the awareness of BC and improvements in diagnostics.
本研究旨在分析立陶宛实施乳房X线筛查计划（MSP）之前及期间局部和晚期乳腺癌（BC）的发病趋势。
研究期分为两个阶段：筛查前阶段（1998 - 2005年）和实施阶段（2006 - 2012年）。对三个年龄组进行分析：0至49岁、50至69岁（目标人群）和70岁以上。
在所有年龄组中，局部乳腺癌的发病率呈稳步上升，而晚期乳腺癌的发病率则有所下降。在目标人群中，研究期间，I期乳腺癌发病率每年统计学显著上升10.3%（从1998年的每10万人3.3例增至2012年的每10万人12.2例）。局部乳腺癌在MSP实施前阶段的增长速度比2006至2012年实施期间更快（分别为10.3%和5.7%）。研究期间晚期乳腺癌观察到略有统计学显著下降（每年-1.1%），而在MSP实施期间未见显著变化。
我们的研究结果表明，立陶宛MSP的实施对局部和晚期乳腺癌的趋势没有显著影响。研究期间观察到的变化，包括筛查前和引入筛查阶段，可能反映了乳腺癌意识的总体趋势和诊断的改善。
