Hu Zhao, Qin Lulu, Xu Huilan
Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410078, China.
Department of Preventive Medicine, Medical School, Hunan University of Chinese Medicine, Changsha 410208, China.
Int J Environ Res Public Health. 2017 Apr 14;14(4):417. doi: 10.3390/ijerph14040417.
: The objective of this study was to evaluate the effectiveness of a synthetic intervention model aimed at preventing type 2 diabetes and controlling plasma glucose, body weight and waist circumference in elderly individuals with prediabetes in rural China. We randomly assigned 434 (180 men and 254 women; mean age, 69 years; mean body mass index, 23.6 kg/m²) with prediabetes to either the intervention group or the control group. Each participant in the intervention group received synthetic intervention for 1 year. The incidence of diabetes was 4.2% in the intervention group, versus 19.7% in the control group at the end of 1 year ( < 0.001). Compared with the control group, the intervention group experienced a great decrease in fasting glucose (-3.9 vs. 2.2 mg/dL, < 0.001), body weight (-3.2 vs. 1.7 kg, < 0.001), waist circumference (-2.4 vs. 1.0 cm, < 0001), total cholesterol (-9.1 vs. -4.6 mg/dL. = 0.014) and HbA1c (-1.0 vs. 0.1 mg %, = 0.002) at the end of 1 year. : The incidence of diabetes of the control group was higher than that of the intervention group. Besides, the synthetic intervention contributes to weight loss and glucose decrease, and may be effective in reducing the risk of diabetes among elderly individuals with prediabetes in rural China.
本研究的目的是评估一种综合干预模式的有效性，该模式旨在预防中国农村地区老年糖尿病前期患者的2型糖尿病，并控制其血糖、体重和腰围。我们将434例糖尿病前期患者（180例男性和254例女性；平均年龄69岁；平均体重指数23.6kg/m²）随机分为干预组和对照组。干预组的每位参与者接受了为期1年的综合干预。1年后，干预组的糖尿病发病率为4.2%，而对照组为19.7%（P<0.001）。与对照组相比，干预组在1年末空腹血糖（-3.9 vs. 2.2mg/dL，P<0.001）、体重（-3.2 vs. 1.7kg，P<0.001）、腰围（-2.4 vs. 1.0cm，P<0.001）、总胆固醇（-9.1 vs. -4.6mg/dL，P = 0.014）和糖化血红蛋白（-1.0 vs. 0.1mg%，P = 0.002）方面均有显著下降。对照组的糖尿病发病率高于干预组。此外，综合干预有助于减轻体重和降低血糖，可能对降低中国农村老年糖尿病前期患者的糖尿病风险有效。
