Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Department of Medicine Health Science Tower, Stony Brook University Hospital, Stony Brook, New York.
Diabetes Metab Res Rev. 2019 Jul;35(5):e3143. doi: 10.1002/dmrr.3143. Epub 2019 Mar 5.
The purpose of this study is to explore the long-term effects of aerobic training (AT), resistance training (RT), and combined training (AT + RT) on the prevention of T2D incidence in patients with prediabetes.
In this randomised controlled trial, people with prediabetes (fasting glucose ≥5.6 and <7.0 mmol/L and/or 2-h glucose ≥7.8 and <11.1 mmol/L on the 75-g oral glucose tolerance test and/or haemoglobin A ≥5.7% and <6.4%) were randomly assigned to the control group, AT group, RT group, or AT + RT group. Supervised exercise programmes, including AT, RT, and AT + RT, were completed for 60 minutes per day, three non-consecutive days per week for 24 months. The primary outcome was the incidence of T2D; secondary outcomes were blood glucose and lipid levels, including total cholesterol (TC) and standard 2-hour oral glucose tolerance (2hPG).
A total of 137 (80%) subjects with a mean age of 59 years (45 men, 92 women) entered the final analysis. After 24 months of intervention, the incidences of T2D adjusted by sex and age were significantly decreased by 74% (95% CI, 38-89), 65% (95% CI, 21-85), and 72% (95% CI, 36-87) in the AT + RT, RT, and AT groups compared with the control group (HR: AT + RT 0.26 [95% CI, 0.11-0.62], RT 0.35 [95% CI, 0.15-0.79], and AT 0.28 [95% CI, 0.13-0.64]). The cumulative T2D incidences were significantly lower in the AT + RT, RT, and AT groups than in the control group (21%, 26%, and 22% vs 69%). The blood glucose and lipid profiles improved more in the AT, RT, and AT + RT groups than in the control group.
RT and RT plus AT were as effective as isolated AT in preventing progression to T2D.
本研究旨在探讨有氧运动（AT）、抗阻运动（RT）和联合训练（AT+RT）对预防糖尿病前期患者 T2D 发病率的长期影响。
在这项随机对照试验中，将糖尿病前期患者（空腹血糖≥5.6 且<7.0mmol/L 和/或 2 小时血糖≥7.8 且<11.1mmol/L 口服葡萄糖耐量试验和/或血红蛋白 A≥5.7%且<6.4%）随机分配至对照组、AT 组、RT 组或 AT+RT 组。接受监督的运动方案，包括 AT、RT 和 AT+RT，每天进行 60 分钟，每周 3 天，共 24 个月。主要结局为 T2D 的发病率；次要结局为血糖和血脂水平，包括总胆固醇（TC）和标准 2 小时口服葡萄糖耐量（2hPG）。
共有 137 名（80%）受试者进入最终分析，平均年龄为 59 岁（45 名男性，92 名女性）。经过 24 个月的干预，AT+RT、RT 和 AT 组 T2D 的发病率分别显著降低 74%（95%CI，38-89）、65%（95%CI，21-85）和 72%（95%CI，36-87），与对照组相比（HR：AT+RT 0.26[95%CI，0.11-0.62]、RT 0.35[95%CI，0.15-0.79]和 AT 0.28[95%CI，0.13-0.64]）。AT+RT、RT 和 AT 组的累积 T2D 发病率明显低于对照组（21%、26%和 22% vs 69%）。与对照组相比，AT、RT 和 AT+RT 组的血糖和血脂谱改善更为明显。
RT 和 RT 联合 AT 与单独 AT 一样有效，可以预防 T2D 的进展。
