用于在活细胞和动物中成像 Cu 的比率型和近红外荧光探针。
A Ratiometric and near-Infrared Fluorescent Probe for Imaging Cu in Living Cells and Animals.
机构信息
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan, 410082, People's Republic of China.
Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Jinan, Shandong, 250022, People's Republic of China.
出版信息
J Fluoresc. 2017 Sep;27(5):1655-1660. doi: 10.1007/s10895-017-2102-6. Epub 2017 Apr 19.
We have rationally constructed a novel ratiometric and near-infrared Cu fluorescent probe based on a tricarbocyanine chromophore. The new probe NIR-Cu showed a ratiometric fluorescent response to Cu with a large emission wavelength shift (up to 142 nm) in the far-red to near-infrared region. The probe also displayed a large variation in the fluorescence ratio (I/I) to Cu species with high sensitivity and selectivity. Additionally, the developed probe NIR-Cu was suitable for fluorescence imaging of Cu in living cells and mice.
我们合理构建了一种新型比率型近红外 Cu 荧光探针，基于三碳菁染料发色团。新型探针 NIR-Cu 对 Cu 表现出比率型荧光响应，在远红至近红外区域有较大的发射波长位移（达 142nm）。该探针对 Cu 物种的荧光比值（I/I）变化也很大，具有高灵敏度和选择性。此外，所开发的探针 NIR-Cu 适用于活细胞和小鼠内 Cu 的荧光成像。
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