Sun Jae June, MD, PhD, Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Korea; Hyuna-taek woo, MD, Sooyouna Cho, MS, Kyounahoon Park, MD, Seokhun Jeong, MD, Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; Yu Jin Lee, MD, PhD, Department of Psychiatry, Seoul National University Hospital, Seoul, Korea; Daehee Kang, MD, PhD, Department of Biomedical Science, Department of Preventive Medicine, Seoul National University College of Medicine and cancer Research Institute, Seoul National University, Seoul, Korea; Aesun Shin, MD, PhD, Department of Preventive Medicine, Seoul National University College of Medicine and cancer Research Institute, Seoul National University, Seoul, Korea.
Sun Jae June, MD, PhD, Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Korea; Hyuna-taek woo, MD, Sooyouna Cho, MS, Kyounahoon Park, MD, Seokhun Jeong, MD, Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea; Yu Jin Lee, MD, PhD, Department of Psychiatry, Seoul National University Hospital, Seoul, Korea; Daehee Kang, MD, PhD, Department of Biomedical Science, Department of Preventive Medicine, Seoul National University College of Medicine and cancer Research Institute, Seoul National University, Seoul, Korea; Aesun Shin, MD, PhD, Department of Preventive Medicine, Seoul National University College of Medicine and cancer Research Institute, Seoul National University, Seoul, Korea
Br J Psychiatry. 2017 Jul;211(1):14-21. doi: 10.1192/bjp.bp.116.186726. Epub 2017 Apr 20.
The association between body size, weight change and depression has not been systematically summarised, especially for individuals who are underweight.To conduct a systematic review and a meta-analysis to examine the association between indices of body size, weight change and depression.A total of 183 studies were selected. Fully adjusted hazard ratios (HRs) or odds ratios (ORs) were extracted. A total of 76 studies contributed to data synthesis with a random-effect model, and subgroup analyses were conducted to evaluate the effect of potential moderators.In cohort studies, underweight at baseline increased the risk of subsequent depression (OR = 1.16, 95% CI 1.08-1.24). Overweight (BMI 25-29.9 kg/m) showed no statistically significant relationship with depression overall; however, the subgroup analyses found different results according to gender (men: OR = 0.84, 95% CI 0.72-0.97, women: OR = 1.16, 95% CI 1.07-1.25). In cross-sectional designs, obesity with BMI >40 kg/m showed a greater pooled odds ratio than obesity with BMI >30 kg/mBoth underweight and obesity increase the risk of depression. The association between overweight and depression differs by gender.
体质量、体重变化与抑郁的关系尚未得到系统总结，尤其是针对体重过轻者。
系统评价和荟萃分析检查体质量指数、体重变化与抑郁之间的关联。
共纳入 183 项研究。提取完全调整后的风险比（HRs）或优势比（ORs）。共有 76 项研究采用随机效应模型进行数据综合，并进行亚组分析以评估潜在混杂因素的影响。
队列研究中，基线时体重过轻增加了随后发生抑郁的风险（OR=1.16，95%CI 1.08-1.24）。总体而言，超重（BMI 25-29.9 kg/m）与抑郁之间无统计学显著关联；但亚组分析根据性别发现了不同的结果（男性：OR=0.84，95%CI 0.72-0.97；女性：OR=1.16，95%CI 1.07-1.25）。在横断面研究中，与 BMI >30 kg/m 肥胖相比，BMI >40 kg/m 肥胖的合并优势比更高。
体重过轻和肥胖都会增加抑郁的风险。超重与抑郁之间的关联因性别而异。
