Jo Soobin, Han Kyung-do, Yoo Juhwan, Shin Dong Wook, Kim Hyewon, Jeon Hong Jin
Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.
Psychiatry Investig. 2024 Dec;21(12):1398-1406. doi: 10.30773/pi.2024.0025. Epub 2024 Dec 23.
Previous studies have investigated obesity and appetite changes in patients with depression, which consisted of a small age range of adults and used body mass index rather than abdominal obesity. The objective of this study is to examine the relationship between abdominal obesity and the risk of depression by sex and age groups.
This study utilized the National Health Insurance Sharing Service (NHISS) database of South Korea, which includes those over 20 years old and who had undergone a health examination in 2009 and their claims data between 2009 and 2018. The diagnosis of depressive episodes was based on the International Statistical Classification of Disease and Related Health Problems 10th revision. Abdominal obesity was measured by waist circumference (WC) and was divided into six levels (cm). Cox proportional-hazard regression analyses were conducted to examine the relationship between abdominal obesity and the risk of depression by sex and age groups.
Among 9,041,751 participants, 1,376,279 were diagnosed with depression. Those with higher WC (90 cm or higher for males, 85 cm or higher for females) showed an increased risk for depression in both sexes (hazard ratio [HR]=1.09, 95% confidence interval [CI]: 1.07-1.11 for males, HR=1.03, 95% CI: 1.02-1.05 for females). Underweight males (WC<80 cm) also showed an increased risk for depression (HR=1.05, 95% CI: 1.04-1.05).
It has been found that higher WC was associated with increased risks of depression in both sexes. Although underweight males showed an elevated risk of depression, a healthy weight is associated with fewer depression symptoms.
以往研究调查了抑郁症患者的肥胖及食欲变化，这些研究涵盖的成年人群年龄范围较小，且使用体重指数而非腹部肥胖指标。本研究的目的是按性别和年龄组考察腹部肥胖与抑郁症风险之间的关系。
本研究利用了韩国国民健康保险共享服务（NHISS）数据库，该数据库包含20岁以上且在2009年接受过健康检查的人群及其2009年至2018年期间的理赔数据。抑郁发作的诊断依据是《疾病和有关健康问题的国际统计分类》第十次修订本。通过腰围（WC）测量腹部肥胖，并将其分为六个等级（厘米）。进行Cox比例风险回归分析，以按性别和年龄组考察腹部肥胖与抑郁症风险之间的关系。
在9,041,751名参与者中，有1,376,279人被诊断为患有抑郁症。腰围较高（男性90厘米及以上，女性85厘米及以上）的人群在两性中患抑郁症的风险均增加（风险比[HR]=1.09，95%置信区间[CI]：男性为1.07 - 1.11，女性HR=1.03，95% CI：1.02 - 1.05）。体重过轻的男性（WC<80厘米）患抑郁症的风险也增加（HR=1.05，95% CI：1.04 - 1.05）。
已发现较高的腰围与两性患抑郁症风险增加有关。虽然体重过轻的男性患抑郁症的风险较高，但健康体重与较少的抑郁症状相关。
