WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.
Sci Rep. 2017 Apr 20;7(1):929. doi: 10.1038/s41598-017-01021-x.
Influenza viruses may cause severe human infections leading to hospitalization or death. Linear regression models were fitted to population-based data on hospitalizations and deaths. Surveillance data on influenza virus activity permitted inference on influenza-associated hospitalizations and deaths. The ratios of these estimates were used as a potential indicator of severity. Influenza was associated with 431 (95% CrI: 358-503) respiratory deaths and 12,700 (95% CrI: 11,700-13,700) respiratory hospitalizations per year. Majority of the excess deaths occurred in persons ≥65 y of age. The ratios of deaths to hospitalizations in adults ≥65 y were significantly higher for influenza A(H1N1) and A(H1N1)pdm09 compared to A(H3N2) and B. Substantial disease burden associated with influenza viruses were estimated in Hong Kong particularly among children and elderly in 1998-2013. Infections with influenza A(H1N1) was suggested to be more serious than A(H3N2) in older adults.
流感病毒可导致严重的人类感染，导致住院或死亡。线性回归模型适用于基于人群的住院和死亡数据。流感病毒活动监测数据可推断与流感相关的住院和死亡情况。这些估计值的比值可用作严重程度的潜在指标。流感每年导致 431 例（95%可信区间：358-503）呼吸道死亡和 12700 例（95%可信区间：11700-13700）例呼吸道住院。大多数超额死亡发生在≥65 岁的人群中。≥65 岁的成年人中，流感 A(H1N1)和 A(H1N1)pdm09 导致的死亡与住院的比值明显高于 A(H3N2)和 B 型。1998-2013 年，香港报告了大量与流感病毒相关的疾病负担，尤其是儿童和老年人。感染流感 A(H1N1)的老年人比感染 A(H3N2)的老年人病情更严重。
