Patnaik A K, Greenlee P G
Department of Pathology, Animal Medical Center, New York, NY.
Vet Pathol. 1987 Nov;24(6):509-14. doi: 10.1177/030098588702400607.
In a retrospective study of 71 primary ovarian tumors in the dog, epithelial tumors (46%) were more common than sex cord stromal (34%) and germ cell tumors (20%). There were more adenocarcinomas (64%) than adenomas. Sex cord stromal tumors were equally divided into Sertoli-Leydig (12/24) and granulosa cell tumors (12/24). There were equal numbers (7/14) of dysgerminomas and teratomas among the germ cell tumors. Most teratomas (6/7) were malignant. Most granulosa cell tumors were solid; two were mostly cystic. Patterns included sheets of round and ovoid to spindle-shaped cells separated by thin, fibrovascular stroma; neoplastic cells formed rosettes or Call-Exner bodies. In some areas, neoplastic cells were in cords or columns and formed cyst-like structures. Four granulosa cell tumors were macrofollicular, having cysts lined with granulosa cells. Median ages of dogs with different ovarian neoplasms were similar; all were more than 10 years old, except the dogs with teratoma (mean age, 4 years). Most neoplasms were unilateral (84%), except the Sertoli-Leydig cell tumors, many of which were bilateral (36%). Size of ovarian neoplasms varied (2 cm3 to 15,000 cm3). Twenty-nine percent of neoplasms metastasized; adenocarcinomas (48%) and malignant teratomas (50%) had the highest rates, and distant metastasis was more common in malignant teratoma. Endometrial hyperplasia was in 67% of the dogs; it was most common in dogs with sex cord stromal tumors (95%). Uterine malignancy was not seen in dogs with granulosa cell tumors, although hyperplasia endometrium was in all dogs with this tumor. Cysts in the contralateral ovaries were most common in dogs with sex cord stromal tumors.
在一项对71例犬原发性卵巢肿瘤的回顾性研究中，上皮性肿瘤（46%）比性索间质肿瘤（34%）和生殖细胞肿瘤（20%）更常见。腺癌（64%）比腺瘤更多。性索间质肿瘤平均分为支持-间质细胞瘤（12/24）和颗粒细胞瘤（12/24）。生殖细胞肿瘤中未成熟畸胎瘤和成熟畸胎瘤数量相等（7/14）。大多数畸胎瘤（6/7）是恶性的。大多数颗粒细胞瘤是实性的；2例主要为囊性。其形态包括由薄的纤维血管间质分隔的圆形、卵圆形至梭形细胞片；肿瘤细胞形成菊形团或Call-Exner小体。在一些区域，肿瘤细胞呈条索状或柱状并形成囊样结构。4例颗粒细胞瘤为大滤泡型，囊肿内衬颗粒细胞。患有不同卵巢肿瘤的犬的中位年龄相似；除了患有畸胎瘤的犬（平均年龄4岁）外，所有犬的年龄均超过10岁。大多数肿瘤是单侧的（84%），除了支持-间质细胞瘤，其中许多是双侧的（36%）。卵巢肿瘤大小各异（2 cm³至15,000 cm³）。29%的肿瘤发生转移；腺癌（48%）和恶性畸胎瘤（50%）的转移率最高，远处转移在恶性畸胎瘤中更常见。67%的犬存在子宫内膜增生；在患有性索间质肿瘤的犬中最常见（95%）。颗粒细胞瘤患犬未出现子宫恶性肿瘤，尽管所有患此肿瘤的犬均有子宫内膜增生。对侧卵巢囊肿在患有性索间质肿瘤的犬中最常见。
