Malagelada Carolina, Malagelada Juan R
Digestive System Research Unit, University Hospital Vall d'Hebron; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd); Department of Medicine, Universitat Autònoma de Barcelona, 08035, Barcelona, Spain.
Curr Gastroenterol Rep. 2017 Jun;19(6):26. doi: 10.1007/s11894-017-0565-x.
Small bowel motility disorders constitute a relatively small but important segment of clinical gastroenterology. Presenting features encompass a broad range of symptom manifestations and severity: from chronic functional-type complaints to life-threatening nutritional impairment. Diagnostic assessment of patients with suspected intestinal motility disorders is often hampered by the complexity of measuring intestinal contractile activity in humans. In this review, we describe and critically comment the main current and forthcoming methodologies.
Beyond conventional small bowel manometry, radiological methods, and intestinal transit tests that have been available for several decades, now we focus on novel methodologies such as high-resolution manometry, magnetic resonance methodology, and endoluminal capsule image analysis. Gradual introduction of new approaches to diagnostic investigation of patients with suspected intestinal motility disorders should facilitate a less invasive and more accurate characterization of disturbed motor function. Enhanced understanding of the pathophysiological basis of clinical conditions should allow better application of therapeutic approaches that are also highlighted in this review.
小肠动力障碍在临床胃肠病学中所占比例相对较小,但却很重要。其表现特征涵盖了广泛的症状表现和严重程度:从慢性功能性主诉到危及生命的营养障碍。对疑似肠道动力障碍患者的诊断评估常常因测量人体肠道收缩活动的复杂性而受阻。在本综述中,我们描述并批判性地评论了当前主要的以及即将出现的方法。
除了已使用数十年的传统小肠测压法、放射学方法和肠道转运试验外,我们现在关注诸如高分辨率测压法、磁共振方法和腔内胶囊图像分析等新方法。逐步引入针对疑似肠道动力障碍患者的新诊断研究方法,应有助于以侵入性较小且更准确的方式对紊乱的运动功能进行表征。对临床病症病理生理基础的深入理解应能更好地应用本综述中也强调的治疗方法。