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炎症性肠病中的肠道运动异常:最新进展。

Abnormal gut motility in inflammatory bowel disease: an update.

机构信息

Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia Medical School, Perugia, Italy.

Clinica Di Gastroenterologia Ed Epatologia, Ospedale Santa Maria della Misericordia, Piazzale Menghini, 1, San Sisto, 06156, Perugia, Italy.

出版信息

Tech Coloproctol. 2020 Apr;24(4):275-282. doi: 10.1007/s10151-020-02168-y. Epub 2020 Feb 15.

DOI:10.1007/s10151-020-02168-y
PMID:32062797
Abstract

BACKGROUND

There is substantial evidence linking disturbed gastrointestinal motility to inflammation. Thus, it is not surprising that abnormalities of gastrointestinal motility play a role in inflammatory bowel disease (IBD), affecting patient outcomes. We performed a review of the literature to investigate the relationship between abnormal gut motility and IBD.

METHODS

With an extensive literature search, we retrieved the pertinent articles linking disturbed gut motility to IBD in various anatomical districts.

RESULTS

The evidence in the literature suggests that abnormal gastrointestinal motility plays a role in the clinical setting of IBD and may confuse the clinical picture.

CONCLUSIONS

Abnormal gut motility may be important in the clinical setting of IBD. However, additional data obtained with modern techniques (e.g., magnetic resonance imaging) are needed to individuate in a more precise manner gastrointestinal motor dysfunctions, to understand the nature of clinical manifestations and properly tailor the treatment of patients.

摘要

背景

有大量证据表明胃肠道蠕动紊乱与炎症有关。因此,胃肠道蠕动异常在炎症性肠病(IBD)中起作用,影响患者的结局,这并不奇怪。我们对文献进行了回顾,以研究异常肠道蠕动与 IBD 之间的关系。

方法

通过广泛的文献检索,我们检索了与不同解剖部位的胃肠道蠕动紊乱与 IBD 相关的相关文章。

结果

文献中的证据表明,异常的胃肠道蠕动在 IBD 的临床环境中起作用,并可能使临床症状复杂化。

结论

异常的肠道蠕动可能在 IBD 的临床环境中很重要。然而,需要使用现代技术(例如磁共振成像)获得更多的数据,以更精确的方式确定胃肠道运动功能障碍,了解临床表现的性质,并为患者的治疗提供适当的指导。

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Therap Adv Gastroenterol. 2019 Feb 19;12:1756284819827689. doi: 10.1177/1756284819827689. eCollection 2019.
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Enteric Glia: A New Player in Abdominal Pain.肠胶质细胞:腹痛的新角色。
Cell Mol Gastroenterol Hepatol. 2019;7(2):433-445. doi: 10.1016/j.jcmgh.2018.11.005. Epub 2018 Nov 24.
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Identification of Specific Oral and Gut Pathogens in Full Thickness Colon of Colitis Patients: Implications for Colon Motility.
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Adv Sci (Weinh). 2025 Mar;12(9):e2408853. doi: 10.1002/advs.202408853. Epub 2025 Jan 10.
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Resolving Resident Colonic Muscularis Macrophage Diversity and Plasticity During Colitis.解析结肠炎期间结肠肌层巨噬细胞的多样性和可塑性
Inflamm Bowel Dis. 2025 Jan 6;31(1):151-168. doi: 10.1093/ibd/izae155.
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