Cernescu C, Popescu L, Constantinescu S, Cernescu S
Stefan S. Nicolau Institute of Virology, Bucharest, Romania.
Virologie. 1988 Apr-Jun;39(2):93-101.
Studies in human embryo fibroblasts infected with measles or herpes simplex virus showed a reduction in virus yield when cultures were pretreated with 1-10 mM lithium chloride doses. Maximum effect was obtained by a 1 h treatment with 10 mM lithium chloride, preceding viral infection by 19-24 hours. A specific antiviral effect against measles virus was manifest immediately after culture pretreatment. Intermittent treatment with 10 mM lithium chloride of cultures persistently infected with measles or herpes virus obtained from human myeloid K-562 cell line shows a reduction in the extracellular virus yield. In the K-562/herpes virus system, the culture treatment with lithium chloride and acyclovir (10 microM) has an additive inhibitory effect on virus production. The paper is focused on the mechanism of lithium chloride antiviral action and the expediency of lithium therapy in SSPE (subacute sclerosing panencephalitis).
对感染麻疹或单纯疱疹病毒的人胚胎成纤维细胞进行的研究表明，当培养物用1-10 mM氯化锂剂量预处理时，病毒产量会降低。在病毒感染前19-24小时用10 mM氯化锂处理1小时可获得最大效果。培养物预处理后立即表现出对麻疹病毒的特异性抗病毒作用。用10 mM氯化锂对从人髓系K-562细胞系获得的持续感染麻疹或疱疹病毒的培养物进行间歇处理，可使细胞外病毒产量降低。在K-562/疱疹病毒系统中，用氯化锂和阿昔洛韦（10 microM）处理培养物对病毒产生具有相加抑制作用。本文重点关注氯化锂抗病毒作用的机制以及锂疗法在亚急性硬化性全脑炎（SSPE）中的适用性。
