Cadario F, Savastio S, Rizzo A M, Carrera D, Bona G, Ricordi C
Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara, Italy.
Eur Rev Med Pharmacol Sci. 2017 Apr;21(7):1604-1609.
In Type 1 Diabetes (T1D) in children, close to the onset the requirements of insulin are often reduced. This represents a transient recovery of endogenous insulin secretion named "honeymoon" because transient and followed by a progressive decline in C-peptide secretion. This case report describes the effect of administration of high dose vitamin D and Ω-3 fatty acids on T1D progression in a 8-year-old child. At today after one year and a half from the onset of T1D, the subject shows a near-normal blood glucose with the administration of 1.5-2 UI of insulin once a day. Thus this report may be of assistance to design additional studies to determine and validate the effect of administration of vitamin D and Ω-3 fatty acids on the progression of T1D.
在儿童1型糖尿病（T1D）中，接近发病时胰岛素需求往往会降低。这代表内源性胰岛素分泌的短暂恢复，称为“蜜月期”，因为它是短暂的，随后C肽分泌会逐渐下降。本病例报告描述了高剂量维生素D和Ω-3脂肪酸给药对一名8岁儿童T1D进展的影响。在T1D发病一年半后的今天，该受试者每天注射1.5 - 2单位胰岛素，血糖接近正常。因此，本报告可能有助于设计更多研究，以确定和验证维生素D和Ω-3脂肪酸给药对T1D进展的影响。
