Inflammation Research Foundation, Peabody, MA 01960, United States.
Antiinflamm Antiallergy Agents Med Chem. 2021;20(2):123-131. doi: 10.2174/1871523019666200512114210.
Inflammation is an acute adaptive response to injury. However, if the initial inflammatory response to an injury is not completely healed, it becomes chronic low-level inflammation that is strongly associated with many chronic disease states, including metabolic (obesity and diabetes), cardiovascular, auto-immune, and neurogenerative disorders as well as cancer. The healing process is far more complex than the initiation of inflammation. Within that complexity of healing is a sequence of events that are under profound dietary control and can be defined by specific blood markers. Those molecular events of the healing process that are under significant dietary control are termed as the Resolution Response. The purpose of this review is to describe the molecular components of the Resolution Response and how different dietary factors can either optimize or inhibit their actions. In particular, those dietary components that optimize the Resolution Response include a calorie-restricted, protein-adequate, moderate-carbohydrate, low-fat diet referred to as the Zone diet, omega-3 fatty acids, and polyphenols. The appropriate combination of these dietary interventions constitutes the foundation of Pro-Resolution Nutrition. The effect of these dietary components the actions of NF-κB, AMPK, eicosanoids, and resolvins are described in this review, as well as ranges of appropriate blood markers that indicate success in optimizing the Resolution Response by dietary interventions.
炎症是对损伤的急性适应性反应。然而，如果对损伤的初始炎症反应未完全治愈，则会变为慢性低水平炎症，这与许多慢性疾病状态密切相关，包括代谢（肥胖和糖尿病）、心血管、自身免疫和神经退行性疾病以及癌症。愈合过程远比炎症的起始复杂得多。在愈合的复杂性中，存在一系列受饮食深刻控制的事件，并可以通过特定的血液标志物来定义。那些受饮食显著控制的愈合过程的分子事件被称为缓解反应。本综述的目的是描述缓解反应的分子成分，以及不同的饮食因素如何促进或抑制它们的作用。特别是，那些优化缓解反应的饮食成分包括热量限制、蛋白质充足、中等碳水化合物、低脂肪的饮食，称为“区域饮食”，ω-3 脂肪酸和多酚。这些饮食干预的适当组合构成了促缓解营养的基础。本文综述了这些饮食成分对 NF-κB、AMPK、类二十烷酸和消退素的作用，以及指示通过饮食干预优化缓解反应成功的适当血液标志物范围。
