Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein Straße 29a, 18059, Rostock, Germany.
Evonik Performance Materials GmbH, Paul-Baumann-Str. 1, 45772, Marl, Germany.
Angew Chem Int Ed Engl. 2017 May 22;56(22):6203-6207. doi: 10.1002/anie.201701950. Epub 2017 Apr 21.
A general palladium-catalyzed synthesis of linear esters directly from sec- and tert-alcohols is described. Compared to the classic Koch-Haaf reaction, which leads to branched products, this new transformation gives the corresponding linear esters in high yields and selectivity. Key for this protocol is the use of an advanced palladium catalyst system with L2 (py bpx) as the ligand. A variety of aliphatic and benzylic alcohols can be directly used and the catalyst efficiency for the benchmark reaction is outstanding (turnover number up to 89 000).
本文描述了一种钯催化的醇直接合成线性酯的通用方法。与经典的 Koch-Haaf 反应（导致支化产物）相比，这种新转化以高产率和选择性得到相应的线性酯。该方案的关键是使用具有 L2（py bpx）作为配体的先进钯催化剂体系。各种脂肪族和苄醇都可以直接使用，对于基准反应，催化剂效率非常高（周转数高达 89000）。
