Karti Omer, Yuksel Bora, Uzunel Umut Duygu, Karahan Eyyup, Zengin Mehmet Ozgur, Kusbeci Tuncay
Department of Ophthalmology, Bozyaka Training and Research Hospital, Izmir, Turkey.
West Eye Hospital, Izmir, Turkey.
Clin Exp Optom. 2017 Nov;100(6):663-667. doi: 10.1111/cxo.12523. Epub 2017 Apr 20.
The aim was to compare the optical coherence tomographic (OCT) parameters of subjects with and without a family history of glaucoma to determine whether positive family history has an impact on retinal nerve fibre layer and ganglion cell complex analyses.
Forty eyes of 40 normal subjects with a proven positive family history (first-degree relatives) for primary open angle glaucoma (POAG) (study group) and age-matched 40 eyes of 40 control subjects without a family history for glaucoma (control group) were enrolled. Retinal nerve fibre layer thickness and macular ganglion cell complex thickness were measured with spectral domain OCT and results were compared between both groups.
In the study group, retinal nerve fibre layer thickness in all quadrants except the superior quadrant was a statistically significant decrease when compared to the control group (p = 0.707 for the superior quadrant, p < 0.05 for other retinal nerve fibre layer parameters; analysis of variance [ANOVA]). Furthermore, ganglion cell complex in all quadrants except the inferotemporal quadrant was a statistically significantly thinner in the study group, when compared with the controls (p = 0.196 for the inferotemporal quadrant, p < 0.05 for ganglion cell complex parameters; ANOVA).
In individuals who have a history of POAG in their first-degree relatives, OCT parameters including retinal nerve fibre layer and ganglion cell complex are significantly lower than the subjects without a family history. Retinal nerve fibre layer and ganglion cell complex thinning were detected in normal-looking discs. The importance of these findings remains uncertain. Prospective, controlled clinical trials with longer follow up are necessary to understand, whether or not those changes are an early indicator of glaucoma.
比较有和没有青光眼家族史的受试者的光学相干断层扫描（OCT）参数，以确定阳性家族史是否对视网膜神经纤维层和神经节细胞复合体分析有影响。
纳入40例有原发性开角型青光眼（POAG）确诊阳性家族史（一级亲属）的正常受试者的40只眼（研究组）和40例无青光眼家族史的年龄匹配的对照受试者的40只眼（对照组）。用光谱域OCT测量视网膜神经纤维层厚度和黄斑神经节细胞复合体厚度，并比较两组结果。
在研究组中，与对照组相比，除上象限外所有象限的视网膜神经纤维层厚度均有统计学意义的降低（上象限p = 0.707，其他视网膜神经纤维层参数p < 0.05；方差分析[ANOVA]）。此外，与对照组相比，研究组中除颞下象限外所有象限的神经节细胞复合体在统计学上明显更薄（颞下象限p = 0.196，神经节细胞复合体参数p < 0.05；ANOVA）。
在一级亲属中有POAG病史的个体中，包括视网膜神经纤维层和神经节细胞复合体在内的OCT参数明显低于无家族史的受试者。在外观正常的视盘中检测到视网膜神经纤维层和神经节细胞复合体变薄。这些发现的重要性仍不确定。需要进行前瞻性、对照的长期随访临床试验，以了解这些变化是否是青光眼的早期指标。
