Graham S, Marshall J, Haughey B, Mittelman A, Swanson M, Zielezny M, Byers T, Wilkinson G, West D
Department of Social and Preventive Medicine, State University of New York, Buffalo 14214.
Am J Epidemiol. 1988 Sep;128(3):490-503. doi: 10.1093/oxfordjournals.aje.a114997.
The authors interviewed 428 pathologically confirmed cases of colon cancer and controls matched on age, sex, race, and neighborhood in the New York counties containing the cities of Buffalo, Niagara Falls, and Rochester. Risk of colon cancer in both males and females, studied separately, appeared to increase with the amount of total fats and total calories ingested. In addition, we found the risk to increase with increases in the Quetelet index of relative weight (weight (kg)/height (m)2). Dietary fiber was only equivocally associated with risk. Fats and Quetelet index were associated with increased risk in a regression analysis adjusting each factor for the other, as well as for fiber, age, and socioeconomic status. The same was true for calories and Quetelet index. Future efforts to clarify a possible protective role for fiber and to disentangle the effects of fats and calories need to be undertaken. The fact that calories ingested and obesity are each associated with increased risk suggests the importance of studying calorie expenditure.
作者对428例经病理确诊的结肠癌病例以及在纽约州包含布法罗市、尼亚加拉瀑布市和罗切斯特市的几个县中按年龄、性别、种族和社区匹配的对照进行了访谈。分别对男性和女性结肠癌风险的研究表明，结肠癌风险似乎随着总脂肪和总热量摄入量的增加而上升。此外，我们发现风险随着体重相对指数（体重（千克）/身高（米）²）的增加而增加。膳食纤维与风险的关联并不明确。在对每个因素进行相互调整以及对纤维、年龄和社会经济地位进行调整的回归分析中，脂肪和体重相对指数与风险增加相关。热量和体重相对指数也是如此。未来需要努力阐明纤维可能的保护作用，并理清脂肪和热量的影响。摄入的热量与肥胖各自都与风险增加相关这一事实表明了研究热量消耗的重要性。
