Drasner K, Bernards C M, Ozanne G M
Department of Anesthesia, University of California, San Francisco.
Anesthesiology. 1988 Sep;69(3):310-2. doi: 10.1097/00000542-198809000-00004.
The authors hypothesized that the analgesia provided by intraspinal opiates would decrease anesthetic requirement. To test this hypothesis, 20 women undergoing major gynecologic surgery were divided randomly into two groups. One group received 0.75 mg morphine sulfate intrathecally, and the other, the same dose intramuscularly (control), prior to the induction of anesthesia with halothane. MAC for halothane was 0.81% in the control group and 0.46% in the intrathecal morphine group (P = 0.024). The reduction in anesthetic requirement due to intrathecal morphine is greater than that produced by low to moderate doses of systemically administered opiates.
作者们推测脊髓内给予阿片类药物所产生的镇痛作用会降低麻醉需求。为验证这一假设，将20例行大型妇科手术的女性随机分为两组。一组在使用氟烷诱导麻醉前经鞘内给予0.75mg硫酸吗啡，另一组（对照组）经肌肉注射相同剂量，氟烷的最低肺泡有效浓度（MAC）在对照组为0.81%，在鞘内注射吗啡组为0.46%（P = 0.024）。鞘内注射吗啡导致的麻醉需求降低幅度大于低至中等剂量全身给药阿片类药物所产生的降低幅度。
