Nishimi Y, Yonemura E, Miwa Y, Fukushima K
Department of Anesthesiology, Keio University School of Medicine, Tokyo.
Masui. 1994 Jul;43(7):980-7.
Intrathecal morphine (Mor) exerts potent analgesic effect and decreases anesthetic requirement. However, morphine was reported to have various uncomfortable side effects, and buprenorphine (BPN) is considered as an alternative opioid. The aim of this study was to investigate the effect of intrathecal BPN and Mor on the MAC of halothane and the relief of postoperative pain. The result shows that the MAC of halothane decreases dose dependently both in the BPN and Mor groups. The decrease in halothane MAC with 0.05 mg intrathecal BPN was equipotent with the intrathecal administration of 0.5 mg Mor. Adequate postoperative analgesia and severe pruritus were observed in the 0.5 mg Mor group. The intrathecal administration of 0.05 mg and 0.075 mg BPN has shown mild analgesic effect without any side effects.
鞘内注射吗啡（Mor）具有强大的镇痛作用，并可降低麻醉需求。然而，据报道吗啡有各种不适的副作用，丁丙诺啡（BPN）被认为是一种替代性阿片类药物。本研究的目的是探讨鞘内注射BPN和Mor对氟烷最低肺泡有效浓度（MAC）及术后疼痛缓解的影响。结果显示，在BPN组和Mor组中，氟烷的MAC均呈剂量依赖性降低。鞘内注射0.05 mg BPN导致氟烷MAC降低的效果与鞘内注射0.5 mg Mor相当。在0.5 mg Mor组观察到充分的术后镇痛和严重瘙痒。鞘内注射0.05 mg和0.075 mg BPN显示出轻度镇痛作用且无任何副作用。
