Kim Johanna Inhyang, Hong Yun-Chul, Shin Choong Ho, Lee Young Ah, Lim Youn-Hee, Kim Bung-Nyun
Department of Public Health Medical Services, Seoul National University Bundang Hospital, 173 bun-gil 82, Goomi-ro, Bundang-gu, Seong-nam City, Gyeonggi-do 13620, Republic of Korea.
Department of Preventive Medicine, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Republic of Korea; Institute of Environmental Medicine, Seoul National University Medical Research Center, 101 Daehakro, Jongno-gu, Seoul 03080, Republic of Korea; Environmental Health Center, Seoul National University College of Medicine, 101 Daehakro, Jongno-gu, Seoul 03080, Republic of Korea.
Environ Res. 2017 Jul;156:519-525. doi: 10.1016/j.envres.2017.04.003. Epub 2017 Apr 26.
The primary purpose of this study was to investigate the effects of phthalate exposure on the intelligence and attentional performance of 6-year old children when adjusting each other as covariates. We also investigated the differential effects of phthalate exposure on the intelligence and attention according to exposure period (maternal or children). Urine concentrations of mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), and mono-n-butyl phthalate (MBP) were analyzed. Multivariable linear regression models were used to investigate the relationship between exposure to various phthalates with IQ scores and continuous performance test (CPT) variables. There were robust associations between child MEHHP and MEOHP levels with full scale IQ (FSIQ) even after adjusting for demographic variables and CPT scores (MEHHP -9.27, 95% CI: -17.25, -1.29; MEOHP -9.83, 95% CI: -17.44, -2.21). Child MEHHP and MEHOP levels negatively affected omission errors (MEHHP -20.36, 95% CI: -34.17, -6.55; MEOHP -18.93, 95% CI: -32.58, -5.28) and the response time variability (MEHHP -21.07, 95% CI: -39.04, -3.10; MEOHP -20.41, 95% CI -38.14, -2.69) of the CPT after adjusting for demographic variables and IQ. Maternal phthalate exposure had no effects on IQ or CPT variables. These results suggest that children phthalate exposure, but not maternal exposure, has an adverse effect on IQ and attentional performance, and these associations were found to be independent of each other.
本研究的主要目的是在将彼此作为协变量进行调整的情况下，调查邻苯二甲酸盐暴露对6岁儿童智力和注意力表现的影响。我们还根据暴露时期（母体或儿童）调查了邻苯二甲酸盐暴露对智力和注意力的不同影响。分析了单-（2-乙基-5-羟基己基）邻苯二甲酸酯（MEHHP）、单-（2-乙基-5-氧代己基）邻苯二甲酸酯（MEOHP）和单-正丁基邻苯二甲酸酯（MBP）的尿液浓度。使用多变量线性回归模型来研究各种邻苯二甲酸盐暴露与智商分数和连续性能测试（CPT）变量之间的关系。即使在调整了人口统计学变量和CPT分数之后，儿童MEHHP和MEOHP水平与全量表智商（FSIQ）之间仍存在显著关联（MEHHP -9.27，95%置信区间：-17.25，-1.29；MEOHP -9.83，95%置信区间：-17.44，-2.21）。在调整了人口统计学变量和智商之后，儿童MEHHP和MEHOP水平对CPT的遗漏错误（MEHHP -20.36，95%置信区间：-34.17，-6.55；MEOHP -18.93，95%置信区间：-32.58，-5.28）和反应时间变异性（MEHHP -21.07，95%置信区间：-39.04，-3.10；MEOHP -20.41，95%置信区间 -38.14，-2.69）产生负面影响。母体邻苯二甲酸盐暴露对智商或CPT变量没有影响。这些结果表明，儿童邻苯二甲酸盐暴露而非母体暴露对智商和注意力表现有不利影响，并且发现这些关联相互独立。
