Cho Soo-Churl, Bhang Soo-Young, Hong Yun-Chul, Shin Min-Sup, Kim Boong-Nyun, Kim Jae-Won, Yoo Hee-Jung, Cho In Hee, Kim Hyo-Won
Department of Psychiatry and Institute of Human Behavioral Medicine, Seoul National University College of Medicine, Republic of Korea.
Environ Health Perspect. 2010 Jul;118(7):1027-32. doi: 10.1289/ehp.0901376. Epub 2010 Mar 1.
Concern over phthalates has emerged because of their potential toxicity to humans.
We investigated the relationship between the urinary concentrations of phthalate metabolites and children's intellectual functioning.
This study enrolled 667 children at nine elementary schools in five South Korean cities. A cross-sectional examination of urine phthalate concentrations was performed, and scores on neuropsychological tests were obtained from both the children and their mothers.
We measured mono-2-ethylhexyl phthalate (MEHP) and mono(2-ethyl-5-oxohexyl)phthalate (MEOHP), both metabolites of di(2-ethylhexyl)phthalate (DEHP), and mono-n-butyl phthalate (MBP), a metabolite of dibutyl phthalate (DBP), in urine samples. The geometric mean (ln) concentrations of MEHP, MEOHP, and MBP were 21.3 microg/L [geometric SD (GSD) = 2.2 microg/L; range, 0.5-445.4], 18.0 microg/L (GSD = 2.4; range, 0.07-291.1), and 48.9 microg/L (GSD = 2.2; range, 2.1-1645.5), respectively. After adjusting for demographic and developmental covariates, the Full Scale IQ and Verbal IQ scores were negatively associated with DEHP metabolites but not with DBP metabolites. We also found a significant negative relationship between the urine concentrations of the metabolites of DEHP and DBP and children's vocabulary subscores. After controlling for maternal IQ, a significant inverse relationship between DEHP metabolites and vocabulary subscale score remained. Among boys, we found a negative association between increasing MEHP phthalate concentrations and the sum of DEHP metabolite concentrations and Wechsler Intelligence Scale for Children vocabulary score; however, among girls, we found no significant association between these variables.
Controlling for maternal IQ and other covariates, the results show an inverse relationship between phthalate metabolites and IQ scores; however, given the limitations in cross-sectional epidemiology, prospective studies are needed to fully explore these associations.
由于邻苯二甲酸盐对人类具有潜在毒性，人们对其愈发关注。
我们调查了邻苯二甲酸酯代谢物的尿液浓度与儿童智力功能之间的关系。
本研究纳入了韩国五个城市九所小学的667名儿童。对尿液中邻苯二甲酸盐浓度进行了横断面检测，并获取了儿童及其母亲的神经心理学测试分数。
我们在尿液样本中检测了邻苯二甲酸二（2-乙基己基）酯（DEHP）的两种代谢物单-2-乙基己基邻苯二甲酸酯（MEHP）和单（2-乙基-5-氧代己基）邻苯二甲酸酯（MEOHP），以及邻苯二甲酸二丁酯（DBP）的代谢物单正丁基邻苯二甲酸酯（MBP）。MEHP、MEOHP和MBP的几何平均（ln）浓度分别为21.3微克/升[几何标准差（GSD）=2.2微克/升；范围，0.5 - 445.4]、18.0微克/升（GSD = 2.4；范围，0.07 - 291.1）和48.9微克/升（GSD = 2.2；范围，2.1 - 1645.5）。在对人口统计学和发育协变量进行调整后，全量表智商和言语智商分数与DEHP代谢物呈负相关，但与DBP代谢物无关。我们还发现DEHP和DBP代谢物的尿液浓度与儿童词汇子分数之间存在显著负相关。在控制了母亲的智商后，DEHP代谢物与词汇子量表分数之间仍存在显著的负相关关系。在男孩中，我们发现MEHP邻苯二甲酸酯浓度升高与DEHP代谢物浓度总和以及韦氏儿童智力量表词汇分数之间存在负相关；然而，在女孩中，我们未发现这些变量之间存在显著关联。
在控制了母亲的智商和其他协变量后，结果显示邻苯二甲酸酯代谢物与智商分数之间存在负相关关系；然而，鉴于横断面流行病学的局限性，需要进行前瞻性研究以充分探索这些关联。
