空腹血糖受损可预测成年女性6年内高血压的发生：中国农村队列研究结果
Impaired fasting glucose predicts the development of hypertension over 6years in female adults: Results from the rural Chinese cohort study.
作者信息
Zhao Yang, Sun Haohang, Wang Bingyuan, Zhang Ming, Luo Xinping, Ren Yongcheng, Zhou Junmei, Han Chengyi, Wang Chongjian, Li Linlin, Zhang Lu, Pang Chao, Yin Lei, Feng Tianping, Zhao Jingzhi, Hu Dongsheng
机构信息
Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China; Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China.
出版信息
J Diabetes Complications. 2017 Jul;31(7):1090-1095. doi: 10.1016/j.jdiacomp.2017.04.006. Epub 2017 Apr 11.
AIMS
To investigate whether impaired fasting glucose (IFG) is an independent risk factor for incident hypertension in a rural Chinese population.
METHODS
We selected 9583 eligible participants 18 to 75years old, who were without hypertension and diabetes at baseline (from 2007 to 2008) and were from a rural area in the middle of China. Concentration of fasting glucose at baseline was assessed in quartiles to predict hypertension risk by gender. Odds ratios (ORs) and 95% confidence intervals (CIs) for IFG (fasting glucose of 100 to 125mg/dl) associated with hypertension were estimated by logistic regression models.
RESULTS
Risk of hypertension was increased for females with glucose levels in quartile 2 (90-96mg/dl), quartile 3 (96-102mg/dl), and quartile 4 (102-125mg/dl) versus quartile 1 (<90mg/dl): OR=1.27 (95% CI=1.01-1.60), 1.30 (1.04-1.63), and 1.55 (1.24-1.93), respectively. During the 6-year follow-up, the cumulative incidence of hypertension was greater for people with IFG than normal fasting glucose (NFG) at baseline (23.9% vs 18.4%, p<0.001 for males and 23.8% vs 16.4%, p<0.001 for females). Risk of incident hypertension was significantly increased for females with IFG versus NFG (OR=1.23 95% CI=1.05-1.45).
CONCLUSIONS
IFG may be an independent risk factor for hypertension in normotensive nondiabetic Chinese females.
目的
调查空腹血糖受损（IFG）是否为中国农村人群新发高血压的独立危险因素。
方法
我们选取了9583名年龄在18至75岁之间、基线时（2007年至2008年）无高血压和糖尿病且来自中国中部农村地区的符合条件的参与者。将基线时的空腹血糖浓度按四分位数进行评估，以按性别预测高血压风险。通过逻辑回归模型估计与高血压相关的IFG（空腹血糖为100至125mg/dl）的比值比（OR）和95%置信区间（CI）。
结果
与四分位数1（<90mg/dl）相比，四分位数2（90 - 96mg/dl）、四分位数3（96 - 102mg/dl）和四分位数4（102 - 125mg/dl）血糖水平的女性患高血压的风险增加：OR分别为1.27（95%CI = 1.01 - 1.60）、1.30（1.04 - 1.63）和1.55（1.24 - 1.93）。在6年的随访期间，基线时患有IFG的人群高血压累积发病率高于空腹血糖正常（NFG）者（男性为23.9%对18.4%，p<0.001；女性为23.8%对16.4%，p<0.001）。与NFG相比，患有IFG的女性发生高血压的风险显著增加（OR = 1.23，95%CI = 1.05 - 1.45）。
结论
IFG可能是血压正常的非糖尿病中国女性患高血压的独立危险因素。
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