Zhang Jie, Yao Xuelin, Chen Yijing, Feng Qing, Zhang Yi, Jiang Tian, Tang Songtao, Zhang Nan, Dai Fang, Hu Honglin, Zhang Qiu
Department of Endocrinology, First Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.
Diabetes Metab Syndr Obes. 2024 Aug 29;17:3227-3238. doi: 10.2147/DMSO.S462748. eCollection 2024.
Diabetes mellitus and hypertension often coexist and share common risk factors. This study investigated the correlation between glycemic management and the prevalence of hypertension among Chinese adults diagnosed with type 2 diabetes mellitus (T2DM).
This study included 1715 patients with T2DM from four cities in Anhui Province, China. Sociodemographic characteristics of the sample participants were collected via questionnaires. A univariate analysis of variance (ANOVA) was utilized for continuous variables, and chi-square testing was used for categorical variables. Binary logistic regression was utilized to examine the relationship between blood pressure and variables including fasting plasma glucose (FPG), glycosylated haemoglobin (HbA1c), body mass index (BMI), waist circumference (WC), physical activity, dyslipidemia, and family history of hypertension.
FPG levels did not increase the risk of hypertension, while HbA1c was significantly and negatively associated with hypertension risk. HbA1c levels ranged from 7.2 to 8.6%, with odds ratios (OR) of 0.68 and 95% confidence intervals (CI) of 0.48 to 0.97 and a significant value of less than 0.05. For the HbA1c levels above 8.6%, the OR was 0.58 with a 95% CI of 0.39 to 0.87 and a significant value of less than 0.01. Furthermore, advanced age, higher BMI, greater waist circumference, presence of dyslipidemia, and positive family history of hypertension were all found to be significantly and independently linked to a heightened risk of developing hypertension. These associations remain significant after further adjustment.
There was a negative association between HbA1c and the risk of hypertension, and the association remained significant after adjustment for antihypertensive drug use.
糖尿病和高血压常并存且具有共同的危险因素。本研究调查了中国成年2型糖尿病（T2DM）患者血糖管理与高血压患病率之间的相关性。
本研究纳入了来自中国安徽省四个城市的1715例T2DM患者。通过问卷调查收集样本参与者的社会人口学特征。连续变量采用单因素方差分析（ANOVA），分类变量采用卡方检验。采用二元逻辑回归分析血压与空腹血糖（FPG）、糖化血红蛋白（HbA1c）、体重指数（BMI）、腰围（WC）、身体活动、血脂异常和高血压家族史等变量之间的关系。
FPG水平未增加高血压风险，而HbA1c与高血压风险呈显著负相关。HbA1c水平在7.2%至8.6%之间，比值比（OR）为0.68，95%置信区间（CI）为0.48至0.97，P值小于0.05，差异有统计学意义。对于HbA1c水平高于8.6%的情况，OR为0.58，95%CI为0.39至0.87，P值小于0.01，差异有统计学意义。此外，高龄、较高的BMI、较大的腰围、血脂异常的存在以及高血压家族史阳性均被发现与高血压发生风险显著且独立相关。进一步调整后，这些关联仍然显著。
HbA1c与高血压风险呈负相关，在调整降压药物使用后，该关联仍然显著。
